Metabolism of Minoxidil, a New Hypotensive Agent: Biotransformation Following Oral Administration to Rats, Dogs, and Monkeys

    August 1975 in “ Journal of Pharmaceutical Sciences ”
    Richard F. Thomas, Harry Harpootlian
    Image of study
    TLDR Minoxidil metabolizes similarly in monkeys and humans, but differently in dogs and rats.
    This study from 47 years ago investigated the biotransformation of minoxidil in rats, dogs, and monkeys following oral administration. The study found that each species excreted substantially the same metabolites but in different relative amounts. The monkey and human exhibited similar metabolite profiles, whereas the dog and rat were quantitatively different from each other and from the monkey and human.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 1000+ results

      community Minoxidil hairs not growing to full length

      in Minoxidil  21 upvotes 2 days ago
      New hair growth from minoxidil and finasteride is not reaching full length, possibly due to slow growth cycles. Users discuss dosing strategies for oral minoxidil to improve efficacy and minimize side effects, with advice against consuming topical minoxidil orally.

      community Minoxidil Dosage

      in Minoxidil  135 upvotes 3 days ago
      The user has been taking 2.5mg of minoxidil daily for 8.5 months without noticeable change and is considering increasing the dose or taking it twice daily. They are aware that many people start with 5mg and are contemplating adjusting their regimen.

      community manager told me i have to stop using minoxidil

      in Minoxidil  599 upvotes 1 week ago
      A manager told an employee to stop using minoxidil, fearing it could unintentionally cause hair growth in others. The conversation is filled with humorous and sarcastic responses, questioning the manager's logic and suggesting the employee continue using the treatment secretly.

      community Minoxidil its giving me huge water retention

      in Minoxidil  128 upvotes 2 weeks ago
      Minoxidil caused water retention and gastrointestinal issues for the user, which improved after stopping the medication. The user is now using finasteride and topical minoxidil, experiencing excessive urination and concerns about systemic absorption.

      community the ordinary retinol & minoxidil

      in Minoxidil  14 upvotes 2 weeks ago
      Using retinol with minoxidil may not be as effective as tretinoin, but retinaldehyde or adapalene could be alternatives. A micro-roller with minoxidil is suggested for better results.

    Similar Research

    5 / 1000+ results