Metabolism of Minoxidil, a New Hypotensive Agent: Biotransformation Following Oral Administration to Rats, Dogs, and Monkeys

August 1975 in “ Journal of Pharmaceutical Sciences ”

Richard F. Thomas, Harry Harpootlian

minoxidil biotransformation metabolites Rogaine

TLDR Minoxidil metabolizes similarly in monkeys and humans, but differently in dogs and rats.

This study from 47 years ago investigated the biotransformation of minoxidil in rats, dogs, and monkeys following oral administration. The study found that each species excreted substantially the same metabolites but in different relative amounts. The monkey and human exhibited similar metabolite profiles, whereas the dog and rat were quantitatively different from each other and from the monkey and human.

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Research cited in this study

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research Pharmacokinetic Studies of Minoxidil

90 citations, May 1972 in “Clinical Pharmacology & Therapeutics”

Minoxidil quickly leaves blood, turns into urine metabolites, and has lasting blood pressure-lowering effects.

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community How much Minoxidil goes systemic?

in Minoxidil 61 upvotes 23 hours ago

The conversation is about the systemic absorption of Minoxidil and the potential switch from topical to oral Minoxidil due to its effectiveness. The user considers oral Minoxidil after experiencing no side effects from a year of using 15% topical Minoxidil.

community Flakey scalp due to minoxidil?

in Minoxidil 7 upvotes 1 week ago

Minoxidil can cause scalp flaking and dryness, often due to its alcohol content. Switching to foam minoxidil or using antifungal shampoos like Ketoconazole may help reduce these side effects.

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in Minoxidil 1630 upvotes 1 week ago

Minoxidil was applied to a single miniaturized hair follicle over four months, resulting in less miniaturization but not yet terminal growth. The user used a 5% minoxidil solution, specifically the Regaine brand, and observed changes using a handheld WiFi microscope.

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in Minoxidil 1 upvotes 2 weeks ago

Foam minoxidil may be a good alternative for those who experience irritation from liquid minoxidil, though opinions on its effectiveness vary. Some users suggest oral minoxidil as a more effective option with fewer side effects at low doses, while others recommend foam or alcohol-free topical versions for sensitive scalps.

community Should I stop minoxidil before a hair transplant to avoid post-surgery shedding?

in Minoxidil 62 upvotes 2 weeks ago

Stopping minoxidil 6 months before a hair transplant may reveal true hair density but could cause shedding. If quitting minoxidil post-transplant, expect potential thinning of minoxidil-dependent hairs; consult a surgeon for advice.

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in Minoxidil 851 upvotes 2 weeks ago

Minoxidil is on sale at Costco, but it poses a significant risk to pets, especially cats. Users discuss the pros and cons of foam versus liquid minoxidil, with some preferring liquid for better results despite its greasiness and dandruff issues.

Similar Research

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research Sulfation of Minoxidil by Human Platelet Sulfotransferase

39 citations, November 1987 in “Clinica Chimica Acta”

Human platelets change minoxidil to minoxidil sulfate, helping blood vessels widen.

research Pharmacology and Pharmacokinetics of Minoxidil

57 citations, January 1980 in “Journal of Cardiovascular Pharmacology”

Minoxidil treats high blood pressure and side effects can be managed.

research Topically Applied Minoxidil in Baldness

26 citations, March 1985 in “International Journal of Dermatology”

Minoxidil helps hair growth, but results vary.

research The History of the Development of Minoxidil

23 citations, October 1988 in “Clinics in Dermatology”

Minoxidil was first made for high blood pressure, but it was later found to help hair growth.

research Topically Applied Minoxidil in Baldness

1 citations, May 2007 in “International Journal of Dermatology”

Minoxidil, when applied to the scalp, can stimulate hair growth but effects vary, stop if treatment ends, and it may cause side effects like fluid retention.