Metabolism of Minoxidil, a New Hypotensive Agent: Biotransformation Following Oral Administration to Rats, Dogs, and Monkeys

    August 1975 in “ Journal of Pharmaceutical Sciences ”
    Richard F. Thomas, Harry Harpootlian
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    TLDR Minoxidil metabolizes similarly in monkeys and humans, but differently in dogs and rats.
    This study from 47 years ago investigated the biotransformation of minoxidil in rats, dogs, and monkeys following oral administration. The study found that each species excreted substantially the same metabolites but in different relative amounts. The monkey and human exhibited similar metabolite profiles, whereas the dog and rat were quantitatively different from each other and from the monkey and human.
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