Metabolism of Minoxidil, a New Hypotensive Agent: Biotransformation Following Oral Administration to Rats, Dogs, and Monkeys

August 1975 in “ Journal of Pharmaceutical Sciences ”

Richard F. Thomas, Harry Harpootlian

minoxidil biotransformation metabolites Rogaine

TLDR Minoxidil metabolizes similarly in monkeys and humans, but differently in dogs and rats.

This study from 47 years ago investigated the biotransformation of minoxidil in rats, dogs, and monkeys following oral administration. The study found that each species excreted substantially the same metabolites but in different relative amounts. The monkey and human exhibited similar metabolite profiles, whereas the dog and rat were quantitatively different from each other and from the monkey and human.

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Research cited in this study

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research Pharmacokinetic Studies of Minoxidil

90 citations , May 1972 in “Clinical Pharmacology & Therapeutics”

Minoxidil quickly leaves blood, turns into urine metabolites, and has lasting blood pressure-lowering effects.

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