Metabolism of Minoxidil, a New Hypotensive Agent: Biotransformation Following Oral Administration to Rats, Dogs, and Monkeys

August 1975 in “ Journal of Pharmaceutical Sciences ”

Richard F. Thomas, Harry Harpootlian

minoxidil biotransformation metabolites Rogaine

TLDR Minoxidil metabolizes similarly in monkeys and humans, but differently in dogs and rats.

This study from 47 years ago investigated the biotransformation of minoxidil in rats, dogs, and monkeys following oral administration. The study found that each species excreted substantially the same metabolites but in different relative amounts. The monkey and human exhibited similar metabolite profiles, whereas the dog and rat were quantitatively different from each other and from the monkey and human.

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Research cited in this study

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research Pharmacokinetic Studies of Minoxidil

90 citations, May 1972 in “Clinical Pharmacology & Therapeutics”

Minoxidil quickly leaves blood, turns into urine metabolites, and has lasting blood pressure-lowering effects.

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community Low-Dose Oral Minoxidil Does Not Significantly Affect BP

in Minoxidil 178 upvotes 1 week ago

Low-dose oral minoxidil is used for hair loss and does not significantly affect blood pressure but may increase heart rate and cause hypotensive symptoms. Some users experience side effects like palpitations and shortness of breath, while others find it effective; topical minoxidil with tretinoin is also considered.

community 4 months topical minoxidil + 2 months finasteride

in Minoxidil 132 upvotes 1 week ago

Topical minoxidil and oral finasteride are effectively promoting hair growth with minimal side effects, such as no impact on sex drive. Users report positive results and reduced hair shedding, with some using a combination of topical foam containing both minoxidil and finasteride.

community Does Nuking Scalp DHT Theoretically Make Minoxidil Gains Permanent?

in Minoxidil 35 upvotes 1 week ago

Minoxidil gains are not permanent without continued use, even with DHT suppression. Combining treatments like Dutasteride, Finasteride, and RU58841 may help maintain hair, but stopping Minoxidil typically results in hair loss.

community Best minoxidil formulation for best results?

in Minoxidil 2 upvotes 1 week ago

The conversation discusses creating a customized minoxidil formulation with tretinoin, azelaic acid, and caffeine, but there are concerns about foam stabilization due to acidity. The user seeks advice on the best formulation for effective results.

community New kirkland minoxidil not as effective?

in Minoxidil 2 upvotes 1 week ago

The user noticed increased hair shedding after switching to a new Kirkland minoxidil with a different formula and is concerned about its effectiveness. They suspect the shedding might be linked to the new minoxidil rather than other factors like changing finasteride dosage or stopping RU58841.

community Have been using topical minoxidil for about 3-4 years now, and it suddenly stopped working. I am now adding tretinoin to the schedule. Anyone experienced this?

in Minoxidil 2 weeks ago

Minoxidil stopped working for OP after 3-4 years, leading them to add tretinoin to their routine. Users suggest trying finasteride for long-term results, despite concerns about side effects.

Similar Research

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research Sulfation of Minoxidil by Human Platelet Sulfotransferase

39 citations, November 1987 in “Clinica Chimica Acta”

Human platelets change minoxidil to minoxidil sulfate, helping blood vessels widen.

research Pharmacology and Pharmacokinetics of Minoxidil

57 citations, January 1980 in “Journal of Cardiovascular Pharmacology”

Minoxidil treats high blood pressure and side effects can be managed.

research Topically Applied Minoxidil in Baldness

26 citations, March 1985 in “International Journal of Dermatology”

Minoxidil helps hair growth, but results vary.

research The History of the Development of Minoxidil

23 citations, October 1988 in “Clinics in Dermatology”

Minoxidil was first made for high blood pressure, but it was later found to help hair growth.

research Topically Applied Minoxidil in Baldness

1 citations, May 2007 in “International Journal of Dermatology”

Minoxidil, when applied to the scalp, can stimulate hair growth but effects vary, stop if treatment ends, and it may cause side effects like fluid retention.