Biotransformation of Finasteride by Ocimum Sanctum L., and Tyrosinase Inhibitory Activity of Transformed Metabolites: Experimental and Computational Insights
December 2014
in “
Steroids
”
TLDR Fermentation of Finasteride with Ocimum sanctum L. creates new metabolite that inhibits tyrosinase.
The study found that the fermentation of Finasteride with Ocimum sanctum L. resulted in three oxidized derivatives, including a new metabolite, which exhibited significant tyrosinase inhibitory activity. The study suggests that biotransformation is a useful method for carrying out structural changes in organic compounds.
