Biotransformation of Finasteride by Ocimum Sanctum L., and Tyrosinase Inhibitory Activity of Transformed Metabolites: Experimental and Computational Insights

December 2014 in “ Steroids ”

Sajid Ali, Muhammad Farrukh Nisar, Marcello Iriti, Mohammad Maroof Shah, Maqsood Mahmud, Ihsan Ali, Inamullah Khan

finasteride Ocimum sanctum tyrosinase biotransformation oxidized derivatives metabolite Propecia Holy Basil

TLDR Fermentation of Finasteride with Ocimum sanctum L. creates new metabolite that inhibits tyrosinase.

The study found that the fermentation of Finasteride with Ocimum sanctum L. resulted in three oxidized derivatives, including a new metabolite, which exhibited significant tyrosinase inhibitory activity. The study suggests that biotransformation is a useful method for carrying out structural changes in organic compounds.

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Research cited in this study

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research Biotransformation of Finasteride (MK-0906) by Selenastrum Capricornutum (Green Algae)

1 citations, December 2006 in “Annals of the New York Academy of Sciences”

Green algae can break down finasteride, reducing environmental harm.

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