A Population Pharmacokinetic Model for Individualized Regimens of Finasteride According to CYP3A5 Genotype and Liver Function

October 2023 in “ Journal of pharmaceutical investigation ”

Ji-Hun Jang, Seung‐Hyun Jeong, Yong‐Bok Lee

finasteride CYP3A5 genotype liver function alanine transaminase ALT clearance steady state concentration Propecia

Studysummary In this study, researchers found that among healthy Korean males, the clearance of finasteride was about 34% lower in individuals with the CYP3A5*3 homozygous allele compared to other genotypes, suggesting dosage adjustments may be necessary considering CYP3A5 and ALT levels to avoid adverse effects.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

15 / 15 results

research Post-Finasteride Syndrome: An Emerging Clinical Problem

26 citations , December 2019 in “Neurobiology of Stress”

This review discusses adverse effects of 5 alpha-reductase inhibitors, particularly persistent side effects such as post-finasteride syndrome, and highlights the need for further investigation.

research Epidemiology and Treatment Modalities for the Management of Benign Prostatic Hyperplasia

110 citations , October 2019 in “Translational Andrology and Urology”

This review discusses current and emerging treatments for benign prostatic hyperplasia and emphasizes the need for further research to optimize treatment selection, but reports no new clinical results.

research Guidelines on the Use of Finasteride in Androgenetic Alopecia

33 citations , January 2016 in “Indian Journal of Dermatology, Venereology and Leprology”

This review discusses the use of finasteride for androgenetic alopecia and highlights that while it is considered safe, there is concern regarding its sexual side effects, which reverse upon discontinuation.

research Bioequivalence Study of Two Different Coated Tablet Formulations of Finasteride in Healthy Volunteers

4 citations , December 2011 in “Drug Research”

This study found that two different 5 mg finasteride tablet formulations are bioequivalent in terms of the rate and extent of absorption in healthy volunteers.

Determination of Finasteride in Human Plasma by Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry with Flow Rate Gradient

research Determination of Finasteride in Human Plasma by Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry with Flow Rate Gradient

2 citations , October 2010 in “European Journal of Drug Metabolism and Pharmacokinetics”

Researchers developed a quick and sensitive way to measure finasteride in blood using a small sample size.

research Rapid Determination of Finasteride in Human Plasma by UPLC-MS/MS and Its Application to Clinical Pharmacokinetic Study

18 citations , April 2010 in “Journal of Chromatography B”

This study describes a validated UPLC-MS/MS method for quantifying finasteride in human plasma, demonstrating higher specificity, improved resolution, increased sensitivity, and faster analysis times compared to conventional HPLC-MS/MS methods.

Bioequivalence of a Single 10-mg Dose of Finasteride 5-mg Oral Disintegrating Tablets and Standard Tablets in Healthy Adult Male Han Chinese Volunteers: A Randomized Sequence, Open-Label, Two-Way Crossover Study

research Bioequivalence of a Single 10-mg Dose of Finasteride 5-mg Oral Disintegrating Tablets and Standard Tablets in Healthy Adult Male Han Chinese Volunteers: A Randomized Sequence, Open-Label, Two-Way Crossover Study

10 citations , October 2009 in “Clinical Therapeutics”

This study found that the orally disintegrating tablet and standard tablet formulations of finasteride met bioequivalence criteria in fasting healthy adult male Han Chinese volunteers, although there was a significant difference in time to maximum concentration.

The Effect of St. John's Wort on the Pharmacokinetics, Metabolism, and Biliary Excretion of Finasteride and Its Metabolites in Healthy Men

research The Effect of St. John's Wort on the Pharmacokinetics, Metabolism, and Biliary Excretion of Finasteride and Its Metabolites in Healthy Men

33 citations , November 2008 in “European Journal of Pharmaceutical Sciences”

This study found that St. John's wort treatment for two weeks induced finasteride metabolism and reduced its plasma exposure in healthy men.

A Rapid, Simple, Specific Liquid Chromatographic–Electrospray Mass Spectrometry Method for the Determination of Finasteride in Human Plasma and Its Application to Pharmacokinetic Study

research A Rapid, Simple, Specific Liquid Chromatographic–Electrospray Mass Spectrometry Method for the Determination of Finasteride in Human Plasma and Its Application to Pharmacokinetic Study

15 citations , November 2006 in “Journal of Pharmaceutical and Biomedical Analysis”

This study developed and validated a reliable method to measure finasteride levels in human plasma, which was successfully used to assess its pharmacokinetics after a 5 mg dose in healthy volunteers.

research Clinical Application of 5α-Reductase Inhibitors

46 citations , March 2001 in “Journal of endocrinological investigation”

This review discusses the use of 5α-reductase inhibitors, particularly finasteride, for treating conditions like benign prostatic hyperplasia, male baldness, and hirsutism, and reports no new clinical results.

research Determination of Finasteride in Human Plasma by Liquid-Liquid Extraction and High-Performance Liquid Chromatography

24 citations , February 2000 in “Journal of Chromatography B: Biomedical Sciences and Applications”

Valid method measures finasteride in plasma, simple, fast, and affordable.

research Finasteride in the Treatment of Men with Frontal Male Pattern Hair Loss

187 citations , June 1999 in “Journal of The American Academy of Dermatology”

This study reported that finasteride 1 mg/day significantly increased hair growth and slowed hair loss in men with frontal scalp hair thinning over one year, and these benefits continued or improved in the second year.

A Model for the Turnover of Dihydrotestosterone in the Presence of the Irreversible 5α-Reductase Inhibitors GI198745 and Finasteride

research A Model for the Turnover of Dihydrotestosterone in the Presence of the Irreversible 5α-Reductase Inhibitors GI198745 and Finasteride

60 citations , December 1998 in “Clinical Pharmacology & Therapeutics”

Both drugs lower DHT levels, with GI198745 being more effective.

research Clinical Pharmacokinetics and Pharmacodynamics of Finasteride

93 citations , January 1996 in “Clinical Pharmacokinectics”

Finasteride helps regrow hair and shrink prostate by reducing DHT, with some sexual side effects.

research Finasteride

86 citations , July 1993 in “Drugs”

Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.