A Population Pharmacokinetic Model for Individualized Regimens of Finasteride According to CYP3A5 Genotype and Liver Function

    October 2023 in “ Journal of pharmaceutical investigation ”
    Ji-Hun Jang, Seung‐Hyun Jeong, Yong‐Bok Lee
    Image of study
    TLDR Finasteride dosages should be adjusted based on CYP3A5 genotype and liver function to avoid side effects.
    This study developed a population pharmacokinetic model to tailor finasteride dosages based on CYP3A5 genotype and liver function, using data from healthy Korean males. It found that individuals with the homozygous CYP3A5*3/*3 genotype had approximately 34% lower clearance of finasteride compared to those with the *1 allele, and higher alanine transaminase (ALT) levels were associated with decreased clearance. The model indicated that the mean finasteride concentration at steady state was 1.59–1.83 times higher in individuals with the *3/*3 genotype and ALT levels above 40 IU/L. These findings suggest that finasteride dosages should be adjusted based on CYP3A5 genotype and liver function to avoid adverse side effects, aiding in its clinical application.
    Discuss this study in the Community →

    Research cited in this study

    15 / 15 results

    Related Community Posts Join

    6 / 1000+ results

      community How to BECOME a RESPONDER to Fin/Dut if you are not responding

      in Finasteride/Dutasteride  306 upvotes 1 year ago
      The conclusion of this conversation is that the user "DuckSeasonCamelSeasn" found that consuming grapefruit juice prior to taking finasteride or dutasteride helped them become a responder to the medications and regain hair growth. However, there are warnings about potential risks and interactions with other medications, so caution should be exercised.

      community How does finasteride leave your body?

      in Chat  13 upvotes 8 months ago
      Finasteride is metabolized in the liver and excreted through urine and feces. Users humorously discuss its excretion, with one joking about it being expelled through ejaculation.

      community Oral Minoxidil and Grapefruit Juice

      in Research/Science  96 upvotes 1 year ago
      The conversation is about the potential dangers of taking oral minoxidil and grapefruit juice together. Some users express concern about dangerous drug interactions, while others argue that grapefruit juice may inhibit the metabolism of finasteride. The conclusion is that grapefruit juice may make finasteride less effective, but it won't affect minoxidil.

    Related Research

    3 / 3 results