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research Mechanical stretch induces hair regeneration through the alternative activation of macrophages

163 citations , April 2019 in “Nature Communications”

This study found that mechanical skin stretching can stimulate hair stem cell proliferation and hair regeneration by activating a complex pathway involving WNT, BMP-2, and M2 macrophages.

research Altered skin development and impaired proliferative and inflammatory responses in transgenic mice overexpressing the glucocorticoid receptor

92 citations , July 2001 in “The FASEB Journal”

In this study, transgenic mice overexpressing the glucocorticoid receptor in certain epithelia showed skin development abnormalities resembling ectodermal dysplasia and exhibited reduced inflammatory responses.

research Alteration of Skin Properties with Autologous Dermal Fibroblasts

67 citations , May 2014 in “International Journal of Molecular Sciences”

This review outlines the role of dermal fibroblasts in wound healing and highlights their potential in developing new cellular therapies, but reports no new clinical results.

research Altered Dermal Fibroblasts in Systemic Sclerosis Display Podoplanin and CD90

47 citations , August 2016 in “American Journal Of Pathology”

This study reports that in systemic sclerosis, CD34+ dermal fibroblasts transition to CD34−, podoplanin+, and CD90+ fibroblasts across the dermis, suggesting a role in unchecked fibrosis.

research Altered autonomic neural control of the cardiovascular system in patients with polycystic ovary syndrome

46 citations , December 2007 in “International Journal of Cardiology”

This study found that patients with polycystic ovary syndrome have reduced heart rate recovery, an exaggerated systolic blood pressure response to exercise, and decreased heart rate variability, implying possible autonomic dysfunction.

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Community Join

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community Can I alternate oral and topical minoxidil?

2 upvotes 2 weeks ago

Alternating between oral and topical minoxidil is considered, with concerns about staining bed sheets. Oral minoxidil may cause more body hair but is less messy than topical.

community Alternatives if can't tolerate minoxidil?

4 upvotes 3 weeks ago

The user is experiencing side effects from oral minoxidil and is considering switching to a topical solution or reducing the dose. They are also using dutasteride and are seeking advice on managing side effects and treatment alternatives.

community Alternatives/unorthodox hairloss protocols to the big three

in Chat 1 upvotes 8 months ago

The conversation discusses alternative and unorthodox hair loss treatments, including RU58841, nandrolone, and dianabol, as well as theoretical approaches involving high doses of estrogen and selective estrogen receptor modulators. These methods are considered extreme and potentially harmful but are explored for those unable to tolerate traditional 5-alpha reductase inhibitors.

community Alternatives to Minox for pet safety

in Minoxidil 2 upvotes 8 months ago

The conversation discusses alternatives to minoxidil for beard growth, focusing on a product called Neofollics Beard Growth Serum, which claims to be effective without using minoxidil. Concerns are raised about its ingredients and effectiveness, especially considering pet safety.

community Alternatives to 5% Foam minoxidil causing redness and itchy scalp

in Treatment 1 upvotes 1 year ago

The user experienced redness and itching from using 5% minoxidil and is considering trying a lower dose or alternative treatments like 2% minoxidil, mesotherapy, PRP, or rosemary oil. They are seeking advice on managing side effects and exploring other options for hair stimulation.

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Learn

6 / 801 results

learn Pyrilutamide

Is pyrilutamide a safer alternative to oral antiandrogens like finasteride? Pyrilutamide may be a safer topical alternative to oral antiandrogens like finasteride.

learn Hair Transplant

What are the non-surgical alternatives to hair transplants? Non-surgical alternatives include PRP therapy, medications, laser therapy, and scalp micropigmentation.

learn Bicalutamide

Is topical bicalutamide a safer alternative to finasteride? There is no published human trial of topical bicalutamide for hair loss, and no licensed topical product exists, so it cannot be called safer than finasteride — or shown to work at all. Oral finasteride has decades of trial data with a documented side-effect profile, and topical finasteride has a phase III trial behind it.

learn Finasteride

Is Finasteride unbeatable or are there equally powerful alternatives? Trials report finasteride as the single medication with the strongest measured effect in male androgenetic alopecia, while dutasteride, minoxidil, topical finasteride, PRP, LLLT and microneedling all have supporting studies and are often reported to work better in combination. Finasteride, dutasteride and oral minoxidil are prescription-only, and several of these uses are off-label.