Advances in Male Hormone Substitution Therapy

As of 2005, there was an increased recognition of male hypogonadism, leading to more frequent use of androgen substitution therapy. Diagnosis was based on clinical signs, symptoms, and low serum testosterone levels. Treatment with androgens generally improved sexual function, mood, muscle mass, and bone density in affected men. However, the potential risks, especially in older men, were not well understood. A variety of delivery systems for androgen therapy were available, with the choice depending on patient and physician preference. Additionally, selective androgen receptor modulators were being considered for their potential to provide targeted biological effects with fewer side effects.