The Effects of Transdermal Dihydrotestosterone in the Aging Male: A Prospective, Randomized, Double-Blind Study
TLDR Dihydrotestosterone gel improved well-being and sexual function in older men without negatively affecting prostate health.
In the 2002 study titled "The Effects of Transdermal Dihydrotestosterone in the Aging Male: A Prospective, Randomized, Double Blind Study," researchers aimed to assess the impact of dihydrotestosterone (DHT) gel on well-being, sexual function, and prostate health in older men. The study included 120 men, aged 50 to 70, who were experiencing symptoms of andropause and had specific serum testosterone and SHBG levels. They were divided into two groups, with 60 receiving DHT and 60 receiving a placebo. Over a period of 6 months, participants applied a transdermal DHT gel with doses ranging from 125 to 250 mg per day. Outcomes were measured using questionnaires for well-being and sexual function, the International Prostate Symptoms Score, transrectal ultrasonography, and serum prostate-specific antigen levels. Of the initial participants, 114 men completed the study.
