Male Sex Hormones, Aging, And Inflammation

January 2023 in “ Biogerontology ”

Justin M. Ketchem, Elizabeth J. Bowman, Carlos M. Isales

testosterone male sex hormones aging inflammation skeletal system muscle tissue adipose tissue cardiovascular system immune system nervous system frailty osteoporosis

The document discusses the importance of adequate testosterone levels for male health, quality of life, and longevity. Testosterone influences various body systems, including skeletal, muscle, adipose tissues, and the cardiovascular, immune, and nervous systems. It also examines the effects of diseases, aging, nutrition, and the environment on testosterone levels. As men age, testosterone levels naturally decline, but the precise mechanisms and health impacts of this decline are not fully understood. Further research is necessary to identify optimal testosterone levels to prevent age-related conditions like frailty and osteoporosis.

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Research cited in this study

6 / 6 results

Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia

research Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia

23 citations , January 2021 in “Biomedicine & Pharmacotherapy”

DHT stops hair regrowth in mice, similar to human hair loss.

research Testosterone Target Therapy: Focus on Immune Response, Controversies, and Clinical Implications in Patients with COVID-19 Infection

21 citations , January 2021 in “Therapeutic Advances in Endocrinology and Metabolism”

Testosterone may have a dual role in COVID-19, potentially worsening outcomes in men, and testosterone therapy could help some patients, but more research is needed.

research Sex-Specific Difference of Hippocampal Synaptic Plasticity in Response to Sex Neurosteroids

22 citations , October 2019 in “Cerebral cortex”

Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.

research Mechanisms of Action of Dehydroepiandrosterone

35 citations , January 2018 in “Vitamins and hormones”

DHEA affects various tissues by interacting with multiple receptors and can be converted into sex hormones.

research Clinical Biochemistry of Dihydrotestosterone

50 citations , February 2013 in “Annals of Clinical Biochemistry”

Understanding how DHT works is important for diagnosing and treating hormone-related disorders.

research Role of 5α-Reductase in Health and Disease

101 citations , April 1994 in “Baillière's clinical endocrinology and metabolism”

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Why do we get bald from evolutionary perspective

in Chat 213 upvotes 4 months ago

Baldness is not an evolutionary disadvantage because it occurs after reproductive age. Treatments like Minoxidil and Finasteride are used for androgenetic alopecia but don't address the root cause.

community Hair loss research is a money grab

in Chat 217 upvotes 1 week ago

Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.

community Testosterone and hair loss seeming irrelevance

in Research/Science 79 upvotes 2 years ago

The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

community Ray Peat: Testosterone Isn’t the Culprit, Prolactin and Cortisol Drive Hair Loss (2016)

in Research/Science 106 upvotes 1 month ago

Prolactin and cortisol are identified as key factors in hair loss, with stress hormones impacting hair shedding. Finasteride and minoxidil are effective treatments, while DHT's role and individual sensitivity are significant factors.

community Does finasteride/dutasteride reverse aging?

in Chat 45 upvotes 1 year ago

Finasteride and dutasteride can improve skin texture and reduce acne by lowering DHT but do not reverse aging. They may enhance skin and hair health for some, but can also cause side effects like dry skin and sexual dysfunction.

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research Men's Health

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research The Interplay Between Finasteride-Induced Androgen Imbalance, Endoplasmic Reticulum Stress, Oxidative Stress, and Liver Disorders in Paternal and Filial Generation

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Finasteride in male rats causes liver and metabolic issues in their offspring.

COVID-19 and Sex Differences: Mechanisms and Biomarkers