Guava Leaf Extract as Bioactive Substances for Anti-Androgen and Antioxidant Activities

    December 2022 in “ Plants ”
    Warintorn Ruksiriwanich, Chiranan Khantham, Anurak Muangsanguan … Sarana Rose Sommano
    Studysummary This study suggests that guava leaf extract may inhibit hair loss by downregulating genes involved in androgen synthesis, potentially offering a natural alternative for treating androgenetic alopecia.
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    Research cited in this study 32

    1. Pumpkin Seed Oil-Loaded Niosomes for Topical Application: 5α-Reductase Inhibitory, Anti-Inflammatory, and Anti-Hair Loss Effects Pharmaceuticals · 2022
    2. Phytochemical Constitution, Anti-Inflammation, Anti-Androgen, and Hair Growth-Promoting Potential of Shallot (Allium Ascalonicum L.) Extract Plants · 2022
    3. Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts Journal of Biomedical Science · 2022
    4. Androgenetic Alopecia From A to Z Springer eBooks · 2022
    5. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    6. Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2 Biology · 2021
    7. Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia Biomedicine & Pharmacotherapy · 2021
    8. Para Rubber Seed Oil: The Safe and Efficient Bio-Material for Hair Loss Treatment Journal of cosmetic dermatology · 2020
    9. Consequences of Steroid-5α-Reductase Deficiency and Inhibition in Vertebrates General and Comparative Endocrinology · 2020
    10. Female Androgenetic Alopecia: An Update on Diagnosis and Management American Journal of Clinical Dermatology · 2019
    11. Physiopathology and Current Treatments of Androgenetic Alopecia: Going Beyond Androgens and Anti-Androgens Dermatologic Therapy · 2019
    12. An Overview of Herbal Alternatives in Androgenetic Alopecia Journal of Cosmetic Dermatology · 2019
    13. Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth International Journal of Cosmetic Science · 2018
    14. Androgen Modulation of Wnt/β-Catenin Signaling in Androgenetic Alopecia Archives of Dermatological Research · 2018
    15. Genetic and Molecular Aspects of Androgenetic Alopecia Indian Journal of Dermatology, Venereology and Leprology · 2018
    16. A Hypothetical Pathogenesis Model for Androgenic Alopecia: Clarifying the Dihydrotestosterone Paradox and Rate-Limiting Recovery Factors Medical Hypotheses · 2017
    17. Minoxidil Acts as an Antiandrogen: A Study of 5α-Reductase Type 2 Gene Expression in a Human Keratinocyte Cell Line PubMed · 2017
    18. 5α-Reductase Isozymes and Aromatase mRNA Levels in Plucked Hair from Young Women with Female Pattern Hair Loss Archives of Dermatological Research · 2017
    19. Androgens and Androgen Receptor Action in Skin and Hair Follicles Molecular and Cellular Endocrinology · 2017
    20. Classifications of Patterned Hair Loss: A Review Journal of Cutaneous and Aesthetic Surgery · 2016
    21. Role of 5α-Reductase Inhibitors in Androgen-Stimulated Skin Disorders PubMed · 2013
    22. Physico-Chemical Properties of Cationic Niosomes Loaded with Fraction of Rice (Oryza sativa) Bran Extract Journal of nanoscience and nanotechnology · 2012
    23. The Role of Androgen and Androgen Receptor in Skin-Related Disorders Archives of Dermatological Research · 2012
    24. Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla Journal of Dermatological Science · 2010
    25. Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride Hormone Molecular Biology and Clinical Investigation · 2010
    26. Hair Growth and Rejuvenation: An Overview Journal of Dermatological Treatment · 2010
    27. Fadrozole And Finasteride Exposures Modulate Sex Steroid- And Thyroid Hormone-Related Gene Expression In Silurana (Xenopus) Tropicalis Early Larval Development General and Comparative Endocrinology · 2009
    28. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007
    29. Female Pattern Hair Loss: Current Treatment Concepts PubMed · 2007
    30. A Random Study of Asian Male Androgenetic Alopecia in Bangkok, Thailand Dermatologic Surgery · 2002
    31. The Prevalence and Types of Androgenetic Alopecia in Korean Men and Women British Journal of Dermatology · 2001
    32. Azasteroids as Inhibitors of Testosterone 5α-Reductase in Mammalian Skin Journal of steroid biochemistry and molecular biology/˜The œJournal of steroid biochemistry and molecular biology · 1993