Guava Leaf Extract as Bioactive Substances for Anti-Androgen and Antioxidant Activities

December 2022 in “ Plants ”

Warintorn Ruksiriwanich, Chiranan Khantham, Anurak Muangsanguan, Yuthana Phimolsiripol, Francisco J. Barba, Korawan Sringarm, Pornchai Rachtanapun, Kittisak Jantanasakulwong, Pensak Jantrawut, Chuda Chittasupho, Romchat Chutoprapat, Korawinwich Boonpisuttinant, Sarana Rose Sommano

TLDR Guava leaf extract may help treat hair loss and protect cells by blocking certain genes and fighting damaging molecules.

The study investigated the anti-androgen and antioxidant properties of guava leaf extract, traditionally used in Thai folk medicine for hair loss. The extract, containing phenolic substances like catechin, gallic acid, and quercetin, significantly downregulated SRD5A1, SRD5A2, and SRD5A3 genes in human prostate cancer cells and hair follicle dermal papilla cells. These genes are involved in the conversion of testosterone to dihydrotestosterone, a potent androgen that contributes to hair follicle shrinkage in androgenetic alopecia. The extract also showed scavenging and chelating abilities, combating the excessive reactive oxygen species that cause premature senescence of hair follicle cells. The study suggests that guava leaf extract could be developed as alternative products or therapeutic adjuvants for the treatment of androgenetic alopecia and other androgen-related disorders.

View this study on mdpi.com →

Discuss this study in the Community →

Cited in this study

32 / 32 results

research Pumpkin Seed Oil-Loaded Niosomes for Topical Application: 5α-Reductase Inhibitory, Anti-Inflammatory, and Anti-Hair Loss Effects

7 citations , July 2022 in “Pharmaceuticals”

Pumpkin Seed Oil in niosomes may help treat hair loss and improve hair growth.

research Phytochemical Constitution, Anti-Inflammation, Anti-Androgen, and Hair Growth-Promoting Potential of Shallot (Allium Ascalonicum L.) Extract

9 citations , June 2022 in “Plants”

research Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts

14 citations , March 2022 in “Journal of Biomedical Science”

Cyanidin 3-O-arabinoside may help treat a common form of hair loss by protecting cells against aging and improving cell function.

research Androgenetic Alopecia From A to Z

2 citations , January 2022 in “Springer eBooks”

research Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics

17 citations , November 2021 in “Journal of Cosmetic Dermatology”

research Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2

14 citations , April 2021 in “Biology”

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

research Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia

23 citations , January 2021 in “Biomedicine & Pharmacotherapy”

DHT stops hair regrowth in mice, similar to human hair loss.

research Para Rubber Seed Oil: The Safe and Efficient Bio-Material for Hair Loss Treatment

6 citations , November 2020 in “Journal of cosmetic dermatology”

Para rubber seed oil is a safe and effective treatment for hair loss.

research Consequences of Steroid-5α-Reductase Deficiency and Inhibition in Vertebrates

21 citations , May 2020 in “General and Comparative Endocrinology”

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

research Female Androgenetic Alopecia: An Update on Diagnosis and Management

43 citations , February 2020 in “American Journal of Clinical Dermatology”

FAGA diagnosis uses blood tests and trichoscopy, with treatments like topical minoxidil, oral anti-androgens, and hormone-modulating drugs.

research Physiopathology and Current Treatments of Androgenetic Alopecia: Going Beyond Androgens and Anti-Androgens

45 citations , September 2019 in “Dermatologic Therapy”

Hair loss treatments work better with lifestyle changes.

research An Overview of Herbal Alternatives in Androgenetic Alopecia

26 citations , August 2019 in “Journal of Cosmetic Dermatology”

Herbal alternatives like saw palmetto and green tea may offer safe, effective treatment for hormonal hair loss.

research Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth

76 citations , October 2018 in “International Journal of Cosmetic Science”

Dermal Papilla cells are a promising tool for evaluating hair growth treatments.

research Genetic and Molecular Aspects of Androgenetic Alopecia

24 citations , May 2018 in “Indian Journal of Dermatology, Venereology and Leprology”

research Androgens and Androgen Receptor Action in Skin and Hair Follicles

100 citations , April 2018 in “Molecular and Cellular Endocrinology”

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

research Androgen Modulation of Wnt/β-Catenin Signaling in Androgenetic Alopecia

39 citations , March 2018 in “Archives of Dermatological Research”

Androgens may block hair growth signals, targeting this could treat hair loss.

research A Hypothetical Pathogenesis Model for Androgenic Alopecia: Clarifying the Dihydrotestosterone Paradox and Rate-Limiting Recovery Factors

30 citations , February 2018 in “Medical Hypotheses”

The model suggests that scalp tension could lead to hair loss, with factors like blood vessel hardening, enlarged oil glands, and poor microcirculation also playing a role. It also hints at a possible link between skull shape and baldness pattern.

research 5α-Reductase Isozymes and Aromatase mRNA Levels in Plucked Hair from Young Women with Female Pattern Hair Loss

21 citations , January 2018 in “Archives of Dermatological Research”

Higher enzyme levels found in women with hair loss, suggesting hormone imbalance.

research Minoxidil Acts as an Antiandrogen: A Study of 5α-Reductase Type 2 Gene Expression in a Human Keratinocyte Cell Line

4 citations , December 2017 in “PubMed”

Minoxidil may help treat hair loss by reducing the activity of a specific enzyme linked to baldness.

research Classifications of Patterned Hair Loss: A Review

101 citations , January 2016 in “Journal of Cutaneous and Aesthetic Surgery”

Different types of hair loss need specific treatments, and while many classification systems exist, each has its flaws; more research is needed to refine these systems and treatments.

research Role of 5α-Reductase Inhibitors in Androgen-Stimulated Skin Disorders

3 citations , February 2013 in “PubMed”

5α-reductase inhibitors like finasteride and dutasteride can help treat skin disorders stimulated by androgens, such as hair loss and acne.

research Physico-Chemical Properties of Cationic Niosomes Loaded with Fraction of Rice (Oryza sativa) Bran Extract

14 citations , September 2012 in “Journal of nanoscience and nanotechnology”

Niosomes with rice bran extract could be useful for anti-hair loss products.

research The Role of Androgen and Androgen Receptor in Skin-Related Disorders

124 citations , July 2012 in “Archives of Dermatological Research”

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

research Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla

122 citations , January 2011 in “Journal of Dermatological Science”

Male pattern baldness involves hormones and cell signals affecting hair growth.

research Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

45 citations , August 2010 in “Hormone Molecular Biology and Clinical Investigation”

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

research Hair Growth and Rejuvenation: An Overview

81 citations , June 2010 in “Journal of Dermatological Treatment”

The document concludes that minoxidil and finasteride are proven for hair growth, herbal remedies show promise, but more research is needed to confirm their effectiveness.

research Fadrozole And Finasteride Exposures Modulate Sex Steroid- And Thyroid Hormone-Related Gene Expression In Silurana (Xenopus) Tropicalis Early Larval Development

60 citations , April 2010 in “General and Comparative Endocrinology”

Fadrozole and finasteride change gene expression related to sex hormones and thyroid hormones in frog larvae development.

research Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes

171 citations , February 2008 in “Journal of Investigative Dermatology”

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.