Guava Leaf Extract as Bioactive Substances for Anti-Androgen and Antioxidant Activities

    December 2022 in “ Plants
    Warintorn Ruksiriwanich, Chiranan Khantham, Anurak Muangsanguan, Yuthana Phimolsiripol, Francisco J. Barba, Korawan Sringarm, Pornchai Rachtanapun, Kittisak Jantanasakulwong, Pensak Jantrawut, Chuda Chittasupho, Romchat Chutoprapat, Korawinwich Boonpisuttinant, Sarana Rose Sommano
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    TLDR Guava leaf extract may help treat hair loss and protect cells by blocking certain genes and fighting damaging molecules.
    The study investigated the anti-androgen and antioxidant properties of guava leaf extract, traditionally used in Thai folk medicine for hair loss. The extract, containing phenolic substances like catechin, gallic acid, and quercetin, significantly downregulated SRD5A1, SRD5A2, and SRD5A3 genes in human prostate cancer cells and hair follicle dermal papilla cells. These genes are involved in the conversion of testosterone to dihydrotestosterone, a potent androgen that contributes to hair follicle shrinkage in androgenetic alopecia. The extract also showed scavenging and chelating abilities, combating the excessive reactive oxygen species that cause premature senescence of hair follicle cells. The study suggests that guava leaf extract could be developed as alternative products or therapeutic adjuvants for the treatment of androgenetic alopecia and other androgen-related disorders.
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