Pumpkin Seed Oil-Loaded Niosomes for Topical Application: 5α-Reductase Inhibitory, Anti-Inflammatory, and Anti-Hair Loss Effects

    July 2022 in “ Pharmaceuticals ”
    Veerawat Teeranachaideekul, Warisara Parichatikanond, Varaporn Buraphacheep Junyaprasert, Boontida Morakul
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    TLDR Pumpkin Seed Oil in niosomes may help treat hair loss and improve hair growth.
    The study explored the use of Pumpkin Seed Oil (PSO)-loaded niosomes as a potential treatment for hair loss. PSO-loaded niosomes, prepared from Tween 20 and cholesterol, showed better skin permeation and hair follicle accumulation than the PSO solution. They inhibited 5α-reductase activity, which can contribute to hair loss, and reduced IL-6 activity, indicating anti-inflammatory properties. A hair scalp serum with PSO-loaded niosomes was tested on 42 panelists and showed no skin irritation. It decreased hair fall by 44.42% and increased the anagen to telogen (A/T) ratio by 1.4-fold after 8 weeks, indicating improved hair growth. The study suggests that PSO-loaded niosomes could be further developed as a hair loss treatment.
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      in Question  68 upvotes 6 years ago
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       6 upvotes 8 years ago
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