Pumpkin Seed Oil-Loaded Niosomes for Topical Application: 5α-Reductase Inhibitory, Anti-Inflammatory, and Anti-Hair Loss Effects

July 2022 in “ Pharmaceuticals ”

Veerawat Teeranachaideekul, Warisara Parichatikanond, Varaporn Buraphacheep Junyaprasert, Boontida Morakul

Pumpkin Seed Oil PSO niosomes 5α-reductase IL-6 anagen telogen Tween 20 cholesterol 5-alpha-reductase interleukin-6

Studysummary This study reports that pumpkin seed oil-loaded niosomes significantly decreased hair loss and increased hair growth indicators in vivo, suggesting potential as a natural anti-hair loss therapy. Our plain-language summary of this paper — not a Tressless recommendation.

The study explored the use of Pumpkin Seed Oil (PSO)-loaded niosomes as a potential treatment for hair loss. PSO-loaded niosomes, prepared from Tween 20 and cholesterol, showed better skin permeation and hair follicle accumulation than the PSO solution. They inhibited 5α-reductase activity, which can contribute to hair loss, and reduced IL-6 activity, indicating anti-inflammatory properties. A hair scalp serum with PSO-loaded niosomes was tested on 42 panelists and showed no skin irritation. It decreased hair fall by 44.42% and increased the anagen to telogen (A/T) ratio by 1.4-fold after 8 weeks, indicating improved hair growth. The study suggests that PSO-loaded niosomes could be further developed as a hair loss treatment.

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