Sexual Side Effects of 5-Alpha-Reductase Inhibitors Finasteride and Dutasteride: A Comprehensive Review

    January 2017 in “ Dermatology Online Journal ”
    Raymond M. Fertig, A. Caresse Gamret, Evan Darwin, Sudeep Gaudi
    TLDR Finasteride and dutasteride can cause sexual problems like impotence and low libido.
    The review examined the sexual side effects of 5-α-reductase inhibitors, specifically finasteride and dutasteride, which were commonly used to treat androgenetic alopecia and benign prostatic hyperplasia. Both drugs effectively reduced dihydrotestosterone levels but were associated with increased incidences of sexual dysfunction, including impotence, decreased libido, and ejaculation disorders. The study compared the sexual side effects of finasteride and dutasteride, as well as the effects at different dosages, providing a comprehensive analysis of the existing medical literature on this topic.
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