Finasteride in the Treatment of Androgenetic Alopecia

    April 2004 in “ Expert Opinion on Pharmacotherapy ”
    James F. Libecco, Wilma F. Bergfeld
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    TLDR Finasteride effectively treats male pattern baldness, improving hair growth and density.
    This document discusses the use of finasteride in the treatment of androgenetic alopecia (AGA) or male pattern baldness. Finasteride inhibits the conversion of testosterone to dihydrotestosterone (DHT), which is responsible for the miniaturization of hair follicles and hair loss. The drug has been approved by the FDA for the treatment of male pattern hair loss at a dose of 1 mg/day and has been found to significantly improve hair growth and density. Finasteride is well-tolerated with a favorable adverse event history, with the most common adverse events being reduced libido, decreased ejaculate volume, and gynecomastia. The document also discusses the pharmacokinetics and metabolism of finasteride, including its absorption, distribution, metabolism, and elimination.
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      community What else is good. Besides the big 3.

      in Chat  34 upvotes 2 months ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community Does finasteride/dutasteride reverse aging?

      in Chat  45 upvotes 2 months ago
      Finasteride and dutasteride can improve skin texture and reduce acne by lowering DHT but do not reverse aging. They may enhance skin and hair health for some, but can also cause side effects like dry skin and sexual dysfunction.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Why is it that low testosterone causes hair loss as well? How can I be balding?

      in Chat  158 upvotes 8 months ago
      The conversation discusses the confusion over low testosterone potentially causing hair loss, with users sharing personal experiences and knowledge about hair loss treatments like Finasteride. Some users suggest that hair follicle sensitivity to DHT, not testosterone levels, is the key factor in balding, and others discuss the side effects of hair loss medications.

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