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    Effects of Finasteride, a Type 2 5-Alpha Reductase Inhibitor, on Fetal Development in the Rhesus Monkey (Macaca Mulatta)

    February 1997 in “ Teratology
    S. Prahalada, Alice F. Tarantal, Gerald F. Harris … Andrew G Hendrickx
    Studysummary This study demonstrated that high oral doses of finasteride caused external genital abnormalities in male rhesus monkey fetuses, but intravenous doses did not lead to abnormalities.
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    Research cited in this study 9

    1. Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP-Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor Journal of the American Chemical Society · 1996
    2. Finasteride: A Slow-Binding 5-Alpha-Reductase Inhibitor Biochemistry · 1993
    3. Critical Developmental Periods for Effects on Male Rat Genitalia Induced by Finasteride, a 5α-Reductase Inhibitor Toxicology and Applied Pharmacology · 1993
    4. The Effect of Finasteride in Men with Benign Prostatic Hyperplasia The New England Journal of Medicine · 1992
    5. Decreased Fertility in Male Rats Administered the 5α-Reductase Inhibitor, Finasteride, Due to Deficits in Copulatory Plug Formation Reproductive Toxicology · 1991
    6. Reversible Decreases of Fertility in Male Sprague-Dawley Rats Treated Orally with Finasteride, a 5α-Reductase Inhibitor Reproductive Toxicology · 1991
    7. External Genitalia Abnormalities in Male Rats Exposed In Utero to Finasteride, a 5α-Reductase Inhibitor Teratology · 1990
    8. Effects of Finasteride (MK-906), a 5α-Reductase Inhibitor, on Circulating Androgens in Male Volunteers The Journal of Clinical Endocrinology and Metabolism · 1990
    9. Species Differences in Prostatic Steroid 5α-Reductases of Rat, Dog, and Human Endocrinology · 1985

    Related research 1

    1. Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men The Journal of Clinical Endocrinology and Metabolism · 1992