Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2

April 2021 in “ Biology ”

Chiranan Khantham, Wipawadee Yooin, Korawan Sringarm, Sarana Rose Sommano, Supat Jiranusornkul, F.D. Carmona, Wutigri Nimlamool, Pensak Jantrawut, Pornchai Rachtanapun, Warintorn Ruksiriwanich

Steroid 5-Alpha Reductase SRD5A SRD5A1 SRD5A2 SRD5A3 Thai rice bran extracts Tubtim Chumphae rice bran TRB x-tocopherol mRNA expression bioactive compounds molecular dynamics simulation 5-Alpha Reductase rice bran extracts tocopherol gene expression

TLDR Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

The study investigated the effects of Thai rice bran extracts on the expression of Steroid 5-Alpha Reductase (SRD5A) genes, which are involved in hair loss. Four varieties of rice bran extracts were used, with Tubtim Chumphae rice bran (TRB) showing the highest sum of overall bioactive compounds and the most effective suppression of SRD5A genes. The study found that these extracts significantly decreased the mRNA expression levels of SRD5A1, SRD5A2, and SRD5A3 genes by 35.79%, 22.26%, and 21.97% respectively. Molecular dynamics simulation showed that x-tocopherol, a component of TRB, had the greatest interaction with SRD5A type 2. The study concluded that x-tocopherol could be developed as an anti-hair loss product.

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