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    Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2

    April 2021 in “ Biology ”
    Chiranan Khantham, Wipawadee Yooin, Korawan Sringarm … Warintorn Ruksiriwanich
    Studysummary This study found that ethanol extract of Tubtim Chumphae rice bran downregulates SRD5A gene expression, similarly to finasteride, suggesting potential use as an anti-hair loss product.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 30

    1. Para Rubber Seed Oil: The Safe and Efficient Bio-Material for Hair Loss Treatment Journal of cosmetic dermatology · 2020
    2. Structure of Human Steroid 5α-Reductase 2 with the Anti-Androgen Drug Finasteride Nature Communications · 2020
    3. Topical Finasteride for the Treatment of Male Androgenetic Alopecia and Female Pattern Hair Loss: A Review of the Current Literature Journal of Dermatological Treatment · 2020
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    6. Quality of Life Assessment in Patients with Androgenetic Alopecia International Journal of Trichology · 2019
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    8. Homology Modeling of 5-Alpha-Reductase 2 Using Available Experimental Data Interdisciplinary sciences: computational life sciences · 2018
    9. 5α-Reductase Isozymes and Aromatase mRNA Levels in Plucked Hair from Young Women with Female Pattern Hair Loss Archives of Dermatological Research · 2017
    10. Association Between Male Pattern Baldness and Prostate Disease: A Meta-Analysis Urologic Oncology: Seminars and Original Investigations · 2017
    11. Androgens and Androgen Receptor Action in Skin and Hair Follicles Molecular and Cellular Endocrinology · 2017
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    13. Androgenetic Alopecia: A Review Endocrine · 2017
    14. Androgens Modify Wnt Agonists/Antagonists Expression Balance in Dermal Papilla Cells Preventing Hair Follicle Stem Cell Differentiation in Androgenetic Alopecia Molecular and Cellular Endocrinology · 2016
    15. Mechanism of Action of Herbs and Their Active Constituents Used in Hair Loss Treatment Fitoterapia · 2016
    16. Male Pattern Baldness in Relation to Prostate Cancer-Specific Mortality: A Prospective Analysis in the NHANES I Epidemiologic Follow-Up Study American Journal of Epidemiology · 2016
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    18. Identification of a New Plant Extract for Androgenic Alopecia Treatment Using a Non-Radioactive Human Hair Dermal Papilla Cell-Based Assay BMC Complementary and Alternative Medicine · 2015
    19. Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride American Journal of Men's Health · 2014
    20. Androgen Actions on the Human Hair Follicle: Perspectives Experimental Dermatology · 2012
    21. Physico-Chemical Properties of Cationic Niosomes Loaded with Fraction of Rice (Oryza sativa) Bran Extract Journal of nanoscience and nanotechnology · 2012
    22. Transfollicular Enhancement of Gel Containing Cationic Niosomes Loaded with Unsaturated Fatty Acids in Rice Bran Semi-Purified Fraction European Journal of Pharmaceutics and Biopharmaceutics · 2012
    23. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011
    24. 5α-Reductase Type 1 Inhibition of Oryza Sativa Bran Extract Prepared by Supercritical Carbon Dioxide Fluid Journal of Supercritical Fluids · 2011
    25. Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride Hormone Molecular Biology and Clinical Investigation · 2010
    26. SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder Cell · 2010
    27. The Extract of Thuja Occidentalis Semen Inhibited 5α-Reductase and Androgenetic Alopecia in B6CBAF1/J Hybrid Mice Journal of dermatological science · 2003
    28. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
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    30. Effect of Topical Application of Vitamin E on the Hair Growth of Rabbits THE JOURNAL OF VITAMINOLOGY · 1965

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