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    Glossary SRD5A3

    enzyme involved in converting testosterone to dihydrotestosterone (DHT)

    SRD5A3 stands for steroid 5 alpha-reductase 3, an enzyme that plays a crucial role in the conversion of testosterone to dihydrotestosterone (DHT), a more potent androgen. This enzyme is also involved in the biosynthesis of dolichol, which is essential for protein glycosylation, a process important for proper cellular function. Mutations in the SRD5A3 gene can lead to congenital disorders such as SRD5A3-CDG (Congenital Disorder of Glycosylation).

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    Research 10 of 495

    1. SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder Cell · 2010 · 260 citations
    2. Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2 Biology · 2021 · 14 citations
    3. In Vitro and In Vivo Regulation of SRD5A mRNA Expression of Supercritical Carbon Dioxide Extract from Asparagus racemosus Willd. Root as Anti-Sebum and Pore-Minimizing Active Ingredients Molecules · 2022 · 8 citations
    4. Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances Plants · 2022 · 7 citations
    5. SRD5A2 and emerging therapies in androgen-driven disorders Nature Reviews Urology · 2026
    6. Bioactive metabolites of edible mushrooms efficacious against androgenic alopecia: Targeting SRD5A2 using computational approach Journal of Herbal Medicine · 2022
    7. Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: No association with female pattern hair loss identified Experimental Dermatology · 2012 · 18 citations
    8. 5α-reduction of epitestosterone is catalysed by human SRD5A1 and SRD5A2 and increases androgen receptor transactivation The Journal of Steroid Biochemistry and Molecular Biology · 2024 · 14 citations
    9. Altered methylation pattern of the SRD5A2 gene in the cerebrospinal fluid of post-finasteride patients: a pilot study Endocrine connections · 2019 · 8 citations
    10. Longer TA repeat but not V89L polymorphisms in the SRD5A2 gene may confer acne risk in the Chinese population Postępy Dermatologii i Alergologii · 2018 · 3 citations
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