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GlossarySRD5A3

enzyme involved in converting testosterone to dihydrotestosterone (DHT)

SRD5A3 stands for steroid 5 alpha-reductase 3, an enzyme that plays a crucial role in the conversion of testosterone to dihydrotestosterone (DHT), a more potent androgen. This enzyme is also involved in the biosynthesis of dolichol, which is essential for protein glycosylation, a process important for proper cellular function. Mutations in the SRD5A3 gene can lead to congenital disorders such as SRD5A3-CDG (Congenital Disorder of Glycosylation).

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research SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder

260 citations , July 2010 in “Cell”

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

research Extensive Challenges and Pending Advances in the Study of 5-Alpha-Reductase Isoenzymes: A Literature Review

August 2024 in “Latin American Journal of Development”

5α-reductase enzymes are crucial in certain disorders, and while treatment advances exist, more research on SRD5A3 is needed.

research Consequences of Steroid-5α-Reductase Deficiency and Inhibition in Vertebrates

21 citations , January 2020 in “General and Comparative Endocrinology”

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

research Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2

14 citations , April 2021 in “Biology”

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

research Subcellular Localization of the Five Members of the Human Steroid 5α-Reductase Family

13 citations , June 2017 in “Biochimie open”

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

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community 28M experiencing thinning - first timer here, please help

in Treatments 370 upvotes 2 weeks ago

A 28-year-old male experiencing hair thinning is considering minoxidil and finasteride. Minoxidil helps regrow hair, while finasteride prevents further loss; both are usually lifelong treatments.

community Anyone experienced weight gain on dutasteride?

in Finasteride/Dutasteride 6 upvotes 3 years ago

Dutasteride can lead to increased cholesterol and liver fat. The user is reconsidering its use due to high cholesterol and lipid levels despite a healthy lifestyle.

community Potential ( but not yet confirmed ) pp405 leak through korean media.

in Research/Science 231 upvotes 1 month ago

A peptide-based hair loss treatment, PP405, reportedly increased hair density by 62% in 90 days, but these claims are unverified and met with skepticism. Users compared PP405 to Minoxidil and Finasteride, expressing doubts about its effectiveness without more evidence.

community Why do we have head hair in first place if we evolved to start losing it in some cases as soon as puberty hits

in Chat 140 upvotes 2 months ago

Hair loss is influenced by genetics and sensitivity to hormones like DHT. Treatments like Minoxidil and finasteride are commonly used, and baldness persists as it doesn't affect reproductive success.

community No fearmongering /just facts on yesterday someone posting on eye issues

in Finasteride/Dutasteride 33 upvotes 7 months ago

Finasteride and dutasteride may not significantly impact meibomian gland function since these glands do not rely on DHT. Some users report dry eyes and other side effects from finasteride, but these may be influenced by other factors or medications.

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