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    Glossary SRD5A3

    enzyme involved in converting testosterone to dihydrotestosterone (DHT)

    SRD5A3 stands for steroid 5 alpha-reductase 3, an enzyme that plays a crucial role in the conversion of testosterone to dihydrotestosterone (DHT), a more potent androgen. This enzyme is also involved in the biosynthesis of dolichol, which is essential for protein glycosylation, a process important for proper cellular function. Mutations in the SRD5A3 gene can lead to congenital disorders such as SRD5A3-CDG (Congenital Disorder of Glycosylation).

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    Research 30 of 417

    1. SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder Cell · 2010 · 260 citations
    2. Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2 Biology · 2021 · 14 citations
    3. In Vitro and In Vivo Regulation of SRD5A mRNA Expression of Supercritical Carbon Dioxide Extract from Asparagus racemosus Willd. Root as Anti-Sebum and Pore-Minimizing Active Ingredients Molecules · 2022 · 8 citations
    4. Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances Plants · 2022 · 7 citations
    5. SRD5A2 and emerging therapies in androgen-driven disorders Nature Reviews Urology · 2026
    6. Bioactive metabolites of edible mushrooms efficacious against androgenic alopecia: Targeting SRD5A2 using computational approach Journal of Herbal Medicine · 2022
    7. Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: No association with female pattern hair loss identified Experimental Dermatology · 2012 · 18 citations
    8. 5α-reduction of epitestosterone is catalysed by human SRD5A1 and SRD5A2 and increases androgen receptor transactivation The Journal of Steroid Biochemistry and Molecular Biology · 2024 · 14 citations
    9. Altered methylation pattern of the SRD5A2 gene in the cerebrospinal fluid of post-finasteride patients: a pilot study Endocrine connections · 2019 · 8 citations
    10. Longer TA repeat but not V89L polymorphisms in the SRD5A2 gene may confer acne risk in the Chinese population Postępy Dermatologii i Alergologii · 2018 · 3 citations
    11. Exploring the clinical implications of novel SRD5A2 variants in 46,XY disorders of sex development Asian Journal of Andrology · 2024 · 2 citations
    12. Multi-target evaluation of Korean herbal compounds against the SRD5A2 / AR / beta-catenin axis for androgenetic alopecia: Boltz-2 cofold, ChEMBL-anchored ranking, ADMET-AI 107-endpoint safety panel, and pilosebaceous single-cell atlas-constrained prioritization of Saponin Re, Emodin, and Biochanin A Zenodo (CERN European Organization for Nuclear Research) · 2026
    13. Multi-target evaluation of Korean herbal compounds against the SRD5A2 / AR / beta-catenin axis for androgenetic alopecia: Boltz-2 cofold, ChEMBL-anchored ranking, ADMET-AI 107-endpoint safety panel, and pilosebaceous single-cell atlas-constrained prioritization of Saponin Re, Emodin, and Biochanin A Zenodo (CERN European Organization for Nuclear Research) · 2026
    14. Multi-target evaluation of Korean herbal compounds against the SRD5A2 / AR / beta-catenin axis for androgenetic alopecia: Boltz-2 cofold, ChEMBL-anchored ranking, ADMET-AI 107-endpoint safety panel, and pilosebaceous single-cell atlas-constrained prioritization of Saponin Re, Emodin, and Biochanin A Zenodo (CERN European Organization for Nuclear Research) · 2026
    15. Multi-target evaluation of Korean herbal compounds against the SRD5A2 / AR / beta-catenin axis for androgenetic alopecia: Boltz-2 cofold, ChEMBL-anchored ranking, ADMET-AI 107-endpoint safety panel, and pilosebaceous single-cell atlas-constrained prioritization of Saponin Re, Emodin, and Biochanin A Open Science Framework · 2026
    16. Multi-target evaluation of Korean herbal compounds against the SRD5A2 / AR / beta-catenin axis for androgenetic alopecia: Boltz-2 cofold, ChEMBL-anchored ranking, ADMET-AI 107-endpoint safety panel, and pilosebaceous single-cell atlas-constrained prioritization of Saponin Re, Emodin, and Biochanin A Zenodo (CERN European Organization for Nuclear Research) · 2026
    17. Identification of xenobiotics interfering with 5 <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline" id="d1e152" altimg="si21.svg"> <mml:mi>α</mml:mi> </mml:math> -reductase (SRD5A2) activity Toxicology Letters · 2026
    18. DNMT1 targets SRD5A2 to induce mitochondrial homeostasis and EMT in urothelial cells of hypospadias Molecular Biology Reports · 2025
    19. MP09-17 METHYLATION OF SRD5A2 IN THE BLOOD AS A NOVEL BIOMARKER TO PREDICT SENSITIVITY TO 5-ARI TREATMENT 2024
    20. Cloning, computational analysis and expression profiling of steroid 5 alpha-reductase 1 (SRD5A1) gene during reproductive phases and ovatide stimulation in endangered catfish, Clarias magur Scientific reports · 2023
    21. Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism bioRxiv (Cold Spring Harbor Laboratory) · 2020
    22. PD02-05 SRD5A2 EXPRESSION IS A PREDICTOR OF RESPONSE TO FINASTERIDE IN THE MTOPS TRIAL The Journal of Urology · 2023
    23. Bioactive metabolites of edible mushrooms efficacious against androgenic alopecia: Targeting SRD5A2 using computational approach Research Square (Research Square) · 2022
    24. 5α-Reduced glucocorticoids: a story of natural selection Journal of Endocrinology · 2011 · 46 citations
    25. 5-α-Reductase type 2 deficiency: is there a genotype-phenotype correlation? A review Hormones · 2018 · 39 citations
    26. Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride Nature Communications · 2020 · 30 citations
    27. Differential expression of steroid 5α-reductase isozymes and association with disease severity and angiogenic genes predict their biological role in prostate cancer Endocrine Related Cancer · 2010 · 30 citations
    28. Consequences of steroid-5α-reductase deficiency and inhibition in vertebrates General and Comparative Endocrinology · 2020 · 21 citations
    29. Subcellular localization of the five members of the human steroid 5α-reductase family Biochimie open · 2017 · 13 citations
    30. Phytochemical Constitution, Anti-Inflammation, Anti-Androgen, and Hair Growth-Promoting Potential of Shallot (Allium ascalonicum L.) Extract Plants · 2022 · 9 citations