Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

August 2010 in “ Hormone Molecular Biology and Clinical Investigation ”

Kazutoshi Yamana, Fernand Labrie, Van Luu-The

type 3 5α-reductase type 1 5α-reductase type 2 5α-reductase finasteride dutasteride androgen metabolism androgen-related disorders Propecia Avodart

From the encyclopedia

Finasteride →

Frontline, gold standard treatment for combatting androgenic alopecia

Dutasteride →

Heavy duty finasteride that comes with higher risks

Studysummary This study found that SRD5a-3 is a highly efficient enzyme for converting hormones into androgens, with dutasteride being a much more potent inhibitor of SRD5a-3 than SRD5a-2.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This 12-year-old study found that human type 3 5α-reductase is expressed at higher levels than types 1 and 2 in peripheral tissues, and its activity is potently inhibited by finasteride and dutasteride. The enzyme may play an important role in androgen metabolism and could be a potential target for treating androgen-related disorders. The study used human tissues from various organs and included enzymatic assays to measure 5α-reductase activity.

View this study on degruyter.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

Biosynthesis of Dihydrotestosterone by a Pathway That Does Not Require Testosterone as an Intermediate in the SZ95 Sebaceous Gland Cell Line

research Biosynthesis of Dihydrotestosterone by a Pathway That Does Not Require Testosterone as an Intermediate in the SZ95 Sebaceous Gland Cell Line

36 citations , October 2009 in “Journal of Investigative Dermatology”

This study suggests that in SZ95 sebocytes, a pathway for DHT biosynthesis does not require testosterone as an intermediate, potentially impacting the treatment of androgen-sensitive skin conditions.

research Androgen Biosynthetic Pathways in the Human Prostate

160 citations , April 2008 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism”

This review outlines the complexities of understanding DHT biosynthesis and metabolism in the human prostate and reports no new findings, emphasizing the need for further research into the pathways involved.

research Structure of Human Type II 5 Alpha-Reductase Gene

76 citations , September 1992 in “Endocrinology”

This study details the isolation and characterization of the human type II 5 alpha-reductase gene, which may play a role in male pseudohermaphroditism, prostate cancer, and benign prostatic hyperplasia.