Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

    August 2010 in “ Hormone Molecular Biology and Clinical Investigation ”
    Kazutoshi Yamana, Fernand Labrie, Van Luu-The
    Studysummary This study found that SRD5a-3 is a highly efficient enzyme for converting hormones into androgens, with dutasteride being a much more potent inhibitor of SRD5a-3 than SRD5a-2.
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    Research cited in this study 3

    1. Biosynthesis of Dihydrotestosterone by a Pathway That Does Not Require Testosterone as an Intermediate in the SZ95 Sebaceous Gland Cell Line Journal of Investigative Dermatology · 2009
    2. Androgen Biosynthetic Pathways in the Human Prostate Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism · 2008
    3. Structure of Human Type II 5 Alpha-Reductase Gene Endocrinology · 1992

    Related research 1

    1. Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride Hormone Molecular Biology and Clinical Investigation · 2010