Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

August 2010 in “ Hormone Molecular Biology and Clinical Investigation ”

Kazutoshi Yamana, Fernand Labrie, Van Luu-The

type 3 5α-reductase type 1 5α-reductase type 2 5α-reductase finasteride dutasteride androgen metabolism androgen-related disorders Propecia Avodart

TLDR Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

This 12-year-old study found that human type 3 5α-reductase is expressed at higher levels than types 1 and 2 in peripheral tissues, and its activity is potently inhibited by finasteride and dutasteride. The enzyme may play an important role in androgen metabolism and could be a potential target for treating androgen-related disorders. The study used human tissues from various organs and included enzymatic assays to measure 5α-reductase activity.

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Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

research Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

45 citations, August 2010 in “Hormone Molecular Biology and Clinical Investigation”

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.