Biosynthesis of Dihydrotestosterone by a Pathway That Does Not Require Testosterone as an Intermediate in the SZ95 Sebaceous Gland Cell Line

    October 2009 in “ Journal of Investigative Dermatology ”
    Melanie Samson, Fernand Labrie, Christos C. Zouboulis, Van Luu-The
    Studysummary This study suggests that in SZ95 sebocytes, a pathway for DHT biosynthesis does not require testosterone as an intermediate, potentially impacting the treatment of androgen-sensitive skin conditions.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on jidonline.org →
    Discuss this study in the Community →

    Research cited in this study 7

    1. Inhibition of 5α-Reductase Activity in SZ95 Sebocytes and HaCaT Keratinocytes In Vitro Hormone and metabolic research · 2007
    2. Sexual Hormones in Human Skin Hormone and metabolic research · 2007
    3. The Human Skin as a Hormone Target and an Endocrine Gland Hormones · 2004
    4. Cutaneous Androgen Metabolism: Basic Research And Clinical Perspectives ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    5. Sebocytes Are the Key Regulators of Androgen Homeostasis in Human Skin ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2001
    6. Intracrinology and the Skin Hormone Research in Paediatrics · 2000
    7. Evidence of Heterogeneity and Quantitative Differences of the Type 1 5α-Reductase Expression in Cultured Human Skin Cells: Evidence of Its Presence in Melanocytes Journal of Investigative Dermatology · 1998