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Overexpression of Aldo-Keto Reductase 1C3 in LNCaP Cells Diverts Androgen Metabolism Towards Testosterone Resulting in Resistance to the 5α-Reductase Inhibitor Finasteride

research Overexpression of Aldo-Keto Reductase 1C3 in LNCaP Cells Diverts Androgen Metabolism Towards Testosterone Resulting in Resistance to the 5α-Reductase Inhibitor Finasteride

45 citations, May 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Biosynthesis of Dihydrotestosterone by a Pathway That Does Not Require Testosterone as an Intermediate in the SZ95 Sebaceous Gland Cell Line

research Biosynthesis of Dihydrotestosterone by a Pathway That Does Not Require Testosterone as an Intermediate in the SZ95 Sebaceous Gland Cell Line

36 citations, October 2009 in “Journal of Investigative Dermatology”

Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.

11α-Hydroxyprogesterone, a Potent 11β-Hydroxysteroid Dehydrogenase Inhibitor, Is Metabolized by Steroid-5α-Reductase and Cytochrome P450 17α-Hydroxylase/17,20-Lyase to Produce C11α-Derivatives of 21-Deoxycortisol and 11-Hydroxyandrostenedione In Vitro

research 11α-Hydroxyprogesterone, a Potent 11β-Hydroxysteroid Dehydrogenase Inhibitor, Is Metabolized by Steroid-5α-Reductase and Cytochrome P450 17α-Hydroxylase/17,20-Lyase to Produce C11α-Derivatives of 21-Deoxycortisol and 11-Hydroxyandrostenedione In Vitro

7 citations, April 2019 in “The Journal of Steroid Biochemistry and Molecular Biology”

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

research Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

45 citations, August 2010 in “Hormone Molecular Biology and Clinical Investigation”

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

research Recent Advances in Drug Design and Drug Discovery for Androgen-Dependent Diseases

11 citations, February 2016 in “Current Medicinal Chemistry”

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

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community Massive study on finasteride side effects released

in Finasteride/Dutasteride 83 upvotes 1 year ago

The release of a study on 5a-reductase inhibitors (finasteride and dutasteride) which showed an increased risk of depression, dementia, decreased libido, and reduced semen load as potential side effects; discussion around other forms of hair loss treatments such as topical minoxidil, RU58841, or opting to accept baldness; and advice to consider professional help for deeper issues related to hair loss.

community Hair follicles do die - my „hair“ is the proof of that statement.

in Female 9 upvotes 1 year ago

The user discusses their experience with hair loss despite taking estrogen and cyproterone, and estimates needing around 3000 grafts for a feminine hairline. They are considering getting the procedure done in Turkey due to high European costs.

community Male pattern baldness, and mental health

in Finasteride/Dutasteride 330 upvotes 9 months ago

A 48-year-old man has been using minoxidil for 15 years and considered finasteride but stopped due to potential side effects. He is concerned about his mental health and the impact of hair loss on self-image, and he encourages support among men experiencing hair loss.

community 2024 guide for male pattern baldness: 10 take home messages from Dr. Moreno-Arrones

in Research/Science 243 upvotes 1 month ago

Effective treatments for male pattern baldness include finasteride, dutasteride, and oral minoxidil. Non-effective approaches include oils, shampoos, serums, laser therapies, massages, vitamins, and microneedling.

community Possible explanation of why Dutasteride seems to be worse for some people’s hair.

in Treatment 47 upvotes 1 year ago

The conclusion of the conversation is that some individuals may experience a condition called reactionary hypergonadism when taking dutasteride for hair loss. This condition can lead to an increase in testosterone levels, which may worsen hair loss instead of improving it.

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