Search

for
Search:

Glossary

Similar Terms

Learn

0 / 0 results

— no results

Research

5 / 1000+ results

Overexpression of Aldo-Keto Reductase 1C3 in LNCaP Cells Diverts Androgen Metabolism Towards Testosterone Resulting in Resistance to the 5α-Reductase Inhibitor Finasteride

research Overexpression of Aldo-Keto Reductase 1C3 in LNCaP Cells Diverts Androgen Metabolism Towards Testosterone Resulting in Resistance to the 5α-Reductase Inhibitor Finasteride

45 citations, May 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Hydroxysteroid Dehydrogenase (17β-HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors: Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels

research Hydroxysteroid Dehydrogenase (17β-HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors: Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels

20 citations, June 2007 in “Recent Patents on Endocrine, Metabolic & Immune Drug Discovery”

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

research Azasteroids as Inhibitors of Testosterone 5α-Reductase in Mammalian Skin

34 citations, February 1993 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

research Recent Advances in Oxasteroids Chemistry

41 citations, March 2007 in “Steroids”

New methods to make oxasteroids show promise for medical treatments like osteoporosis and breast cancer.

research HSD3B1 Genotypes Conferring Adrenal-Restrictive and Adrenal-Permissive Phenotypes in Prostate Cancer and Beyond

30 citations, July 2019 in “Endocrinology”

Certain HSD3B1 gene types are linked to worse prostate cancer outcomes and affect treatment response and other health conditions.

View more "5a-androstane-3 17-dione" in research →

Community Join

5 / 163 results

community Finasteride affects both 5a reductase and 5b reductase

6 upvotes 5 years ago

Finasteride not only inactivates the 5a reductase enzyme but also affects the 5b reductase enzyme in a dose-dependent manner, which can impact sexual behavior and brain activity. The user experienced significant hair regrowth and side effects on 1mg of finasteride, which diminished after reducing the dose to 0.5mg, leading to no side effects and further hair improvement.

community From the research study: "Dihydrotestosterone and the concept of 5a-reductase inhibition in human benign prostatic hyperplasia" - G. Bartsch, R.S. Rittmaster, H. Klocker (2002) in the "World Journal of Urology".

in Research/Science 23 upvotes 2 years ago

Dutasteride is a stronger 5AR inhibitor than finasteride and can significantly lower DHT levels. Reduced doses of dutasteride may lower side effects.

community A repository of links to current scientific research and findings into the nature of and relating to side-effects for Finasteride/Dutasteride/5a-reductase inhibitors.

in Finasteride 17 upvotes 5 years ago

Finasteride and dutasteride, used for hair loss, can cause sexual dysfunction, depression, and suicidal thoughts, with some effects persisting after stopping. The post stresses the importance of being aware of these risks.

community Massive study on finasteride side effects released

in Finasteride/Dutasteride 83 upvotes 2 years ago

The release of a study on 5a-reductase inhibitors (finasteride and dutasteride) which showed an increased risk of depression, dementia, decreased libido, and reduced semen load as potential side effects; discussion around other forms of hair loss treatments such as topical minoxidil, RU58841, or opting to accept baldness; and advice to consider professional help for deeper issues related to hair loss.

community All my gains from minoxidil fell out years later

in Finasteride/Dutasteride 48 upvotes 2 weeks ago

The user experienced hair loss after initially gaining hair with minoxidil and is now using dutasteride and oral minoxidil alongside topical minoxidil, hoping to regain lost hair. There is uncertainty about the effectiveness of these treatments, with some users suggesting that blocking DHT might help, while others express skepticism about regrowth.

View more "5a-androstane-3 17-dione" in community →