TLDR DHT in the human prostate is produced through multiple pathways, not just from testosterone.
The document discussed androgen biosynthesis in the human prostate, focusing on the roles of testosterone (T) and dihydrotestosterone (DHT). It highlighted that T is produced in the testis and acts directly to promote male characteristics, while DHT, a more active androgen, is formed from T. The study proposed a new biosynthetic pathway for DHT that does not require T, suggesting two separate pathways for T and DHT biosynthesis. This new pathway could potentially resolve the previously unsolved problem of androgen physiology, where both T and DHT activate the same androgen receptor.
403 citations
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November 2005 in “Journal of Endocrinology” Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.
76 citations
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September 1992 in “Endocrinology” The human type II 5α-reductase gene has a specific structure important for understanding certain medical conditions.
354 citations
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August 1991 in “Molecular Endocrinology” Human adrenals and gonads have a unique enzyme for steroid hormone production.
January 2004 in “Elsevier eBooks” Anti-androgen drugs can treat conditions like prostate cancer and male pattern baldness by blocking effects of testosterone and DHT.
November 2014 in “Elsevier eBooks” Gene mutations can cause problems in male genital development.
59 citations
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September 2003 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” Epitestosterone may counteract testosterone's effects and has roles in body processes like prostate growth and hair distribution.
35 citations
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May 2022 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism” Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.
11 citations
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February 2016 in “Current Medicinal Chemistry” New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.
