Androgen Biosynthetic Pathways in the Human Prostate

    April 2008 in “ Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism ”
    Van Luu‐The, Alain Bélanger, Fernand Labrie
    TLDR DHT in the human prostate is produced through multiple pathways, not just from testosterone.
    The document discussed androgen biosynthesis in the human prostate, focusing on the roles of testosterone (T) and dihydrotestosterone (DHT). It highlighted that T is produced in the testis and acts directly to promote male characteristics, while DHT, a more active androgen, is formed from T. The study proposed a new biosynthetic pathway for DHT that does not require T, suggesting two separate pathways for T and DHT biosynthesis. This new pathway could potentially resolve the previously unsolved problem of androgen physiology, where both T and DHT activate the same androgen receptor.
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