TLDR Gene mutations can cause problems in male genital development.
The article discussed the critical role of dihydrotestosterone in the formation of male external genitalia during 8–12 weeks of gestation, driven by chorionic gonadotropin-stimulated Leydig cells converting cholesterol to testosterone and then to dihydrotestosterone. It highlighted how mutations in genes encoding enzymes, cofactor proteins, receptors, and stimulatory hormones involved in this process could lead to congenital anomalies in androgen production and male pseudo-hermaphroditism, detailing the clinical and biochemical features of these genetic mutations.
May 2023 in “IntechOpen eBooks” More research is needed to understand how testosterone is maintained in adult males.
5 citations,
January 2017 in “Endocrinology” Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.
50 citations,
February 2013 in “Annals of Clinical Biochemistry” Understanding how DHT works is important for diagnosing and treating hormone-related disorders.
34 citations,
July 2020 in “Frontiers in immunology” Androgens may influence T cells, contributing to higher autoimmune liver disease risk in women.
218 citations,
December 2011 in “Advances in Urology” The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.
