Clinical Biochemistry of Dihydrotestosterone

    February 2013 in “ Annals of Clinical Biochemistry
    Paula M Marchetti, Julian H. Barth
    Image of study
    TLDR Understanding how DHT works is important for diagnosing and treating hormone-related disorders.
    The 2013 review "Clinical biochemistry of dihydrotestosterone" discussed the role and metabolism of dihydrotestosterone (DHT), a potent androgen hormone. DHT is involved in sexual development, hair growth, and sebum production, and is linked to conditions such as androgenetic alopecia, 5-alpha-reductase deficiency, and polycystic ovary syndrome. The document highlighted that over 300 mutations in the androgen receptor can lead to androgen resistance, affecting the body's response to hormones like DHT. It also noted that males with 5α reductase type 2 deficiency have high testosterone levels but decreased DHT concentrations. The review also discussed the use of finasteride, a 5α reductase inhibitor, in improving hair growth and reducing scalp DHT. The document concluded that understanding the biochemistry of DHT is crucial for diagnosing and treating various endocrine disorders.
    Discuss this study in the Community →

    Research cited in this study

    27 / 27 results

    Related Community Posts Join

    6 / 138 results

      community Why is it that low testosterone causes hair loss as well? How can I be balding?

      in Chat  158 upvotes 8 months ago
      The conversation discusses the confusion over low testosterone potentially causing hair loss, with users sharing personal experiences and knowledge about hair loss treatments like Finasteride. Some users suggest that hair follicle sensitivity to DHT, not testosterone levels, is the key factor in balding, and others discuss the side effects of hair loss medications.

    Similar Research

    5 / 1000+ results