Genetic Analysis of Male Pattern Baldness and the 5α-Reductase Genes

June 1998 in “ Journal of Investigative Dermatology ”

Justine A. Ellis, Margaret Susanne Stebbing, Stephen Harrap

male pattern baldness 5α-reductase SRD5A1 SRD5A2 polygenic etiology MPB

Studysummary This study found no significant genetic association between the 5α-reductase enzyme genes and male pattern baldness, suggesting a polygenic etiology rather than simple inheritance.

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research Can Male-Pattern Baldness Be Prevented? Promising Results from a Study on Treating Male-Pattern Baldness with Oral Finasteride

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Keith Kaufman reported promising results on treating male-pattern baldness with oral finasteride at the World Congress of Dermatology.

research Improvement in Androgenetic Alopecia (Stage V) Using Topical Minoxidil in a Retinoid Vehicle and Oral Finasteride

23 citations , December 1995 in “Archives of Dermatology”

This case report discusses a 32-year-old man's treatment for advanced androgenetic alopecia using a combination of topical minoxidil and oral finasteride, but no clinical outcomes are detailed.

research Androgenetic Alopecia: An Autosomal Dominant Disorder

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Hair loss in androgenetic alopecia is caused by genetic factors and androgen excess, and can be treated with combined therapies.

The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness

research The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness

59 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that 4 weeks of finasteride treatment significantly decreased DHT levels in bald scalp to levels similar to hair-containing scalp in men with male pattern baldness.

research Role of 5α-Reductase in Health and Disease

101 citations , April 1994 in “Baillière's clinical endocrinology and metabolism”

This review discusses the role of 5α-reductase enzymes in androgen action and related disorders, noting that their specific inhibitory drugs show promise for conditions like benign prostatic hypertrophy; it reports no new clinical results.

Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque

research Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque

34 citations , February 1992 in “The Journal of Clinical Endocrinology and Metabolism”

In this study, the combination of finasteride and minoxidil significantly increased hair growth in balding male stumptail macaques compared to each drug alone.

research Endothelium-Derived Relaxing Factor and Minoxidil: Active Mechanisms in Hair Growth

15 citations , August 1989 in “Archives of Dermatology”

This article hypothesizes that minoxidil may act as an endothelium-derived relaxing factor agonist, which could explain both its vasodilatory properties and its potential effect on hair growth; however, it reports no new experimental results.

research The Inheritance Of Common Baldness: To Be Or Not To Be?

203 citations , November 1984 in “Journal of the American Academy of Dermatology”

This study presents evidence suggesting that androgenetic alopecia is most likely inherited through a polygenic model, challenging the traditional view that it is caused by a simple Mendelian autosomal dominant gene.