Endothelium-Derived Relaxing Factor and Minoxidil: Active Mechanisms in Hair Growth

    August 1989 in “ Archives of Dermatology ”
    Peter Proctor
    TLDR Minoxidil may promote hair growth by mimicking a natural body chemical.
    The document discussed the potential role of the nitroxide free radical (NO), identified as endothelium-derived relaxing factor (EDRF), in vascular physiology and its implications for hair growth. It suggested that minoxidil, a known vasodilator, might act as an EDRF agonist, sharing similar mechanisms by activating guanylate cyclase. This activation was believed to account for their vasodilatory properties. The document proposed that EDRF might have a separate action on hair growth, which could explain the effects of minoxidil in promoting hair growth.
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      community Comprehensive Microneedling Guide

      in Microneedling  292 upvotes 3 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community only microneedling and supplements

      in Progress Pictures  67 upvotes 4 months ago
      The user used microneedling, zinc, vitamin D3, biotin, magnesium, saw palmetto, pumpkin seed oil, and a DHT-blocker shampoo with biotin for hair loss. They are considering adding minoxidil due to stagnation in progress.

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      in Microneedling  15 upvotes 4 months ago
      Stopping microneedling may result in losing hair gains, as it enhances the effectiveness of treatments like minoxidil. Combining microneedling with minoxidil and finasteride is more effective than using microneedling alone.

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      in Treatment  42 upvotes 5 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community What can be the real reason of Finasteride SE ?

      in Finasteride/Dutasteride  19 upvotes 5 months ago
      Finasteride can cause side effects like erectile dysfunction and decreased libido, possibly due to increased estradiol from testosterone aromatization, especially in those with higher body fat. Side effects vary widely and may also be influenced by genetic factors or neurosteroid inhibition.

      community Sugar and Hair loss connections

      in Research/Science  41 upvotes 7 months ago
      High sugar diets may worsen hair loss by increasing 5α-reductase activity and androgen levels, especially in women with PCOS. A low sugar diet might reduce scalp DHT levels, similar to finasteride, but genetics also significantly influence hair loss.

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