Agent: Minoxidil

    January 2018 in “ Elsevier eBooks ”
    David C. McMillan, L Wagner, Charlotte Kenreigh
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    TLDR Minoxidil helps lower severe blood pressure and promotes hair growth but can have serious side effects and must be used continuously.
    Minoxidil, as of 2018, was used to treat severe hypertension orally as a last-resort arterial vasodilator and topically for alopecia to promote hair growth, although its exact mechanisms were not fully understood. The medication, a prodrug, becomes bioactivated in the liver or hair follicles to its active form. Oral use carried a high risk of systemic toxicity, necessitating careful monitoring due to side effects like tachycardia and edema, and was contraindicated for patients with pheochromocytoma. Topical use needed to be continuous, as ceasing application would result in the loss of hair growth benefits. Minoxidil was deemed neither carcinogenic nor mutagenic in rodent studies.
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      in Research/Science  3 upvotes 1 month ago
      DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.

      community Being Safe on Oral Minoxidil: tl;dr on the literature.

      in Research/Science  51 upvotes 2 months ago
      Oral minoxidil is effective for hair loss but can cause cardiovascular side effects, such as pericardial effusion, especially in those with genetic predispositions. Starting with low doses and monitoring cardiovascular health are advised to reduce risks.

      community When are we getting a cure to hair loss?

      in Chat 2 years ago
      Potential treatments for hair loss, including Minoxidil, finasteride, RU58841 and various upcoming pharmaceuticals, gene editing and cloning. It is suggested that a cure, if found, would be highly profitable due to the large number of people affected by hair loss globally.

      community Extreme hair and beard growth from Stemoxydine. Big 3 + 1?

      in Product  23 upvotes 4 years ago
      Using a combination of Stemoxydine, minoxidil, dutasteride, and keto shampoo to achieve extreme hair and beard growth. The user has experienced positive results with terminal hairs at the hairline and an increase in density to their stubble after several weeks of use.

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