Search

for
Search:

Glossary5α-reductase (SRD5A)

enzyme converting testosterone into potent dihydrotestosterone (DHT)

5α-reductase is an enzyme that converts testosterone into dihydrotestosterone (DHT), a more potent androgen hormone. This enzyme plays a significant role in various biological processes, including the development of male characteristics and the regulation of hair growth. Inhibitors of 5α-reductase, such as finasteride, are commonly used to treat conditions like male pattern baldness and benign prostatic hyperplasia.

Related Terms

Learn

0 / 0 results

— no results

Research

5 / 458 results

In Vitro and In Vivo Regulation of SRD5A mRNA Expression of Supercritical Carbon Dioxide Extract from Asparagus Racemosus Root as Anti-Sebum and Pore-Minimizing Active Ingredients

research In Vitro and In Vivo Regulation of SRD5A mRNA Expression of Supercritical Carbon Dioxide Extract from Asparagus Racemosus Root as Anti-Sebum and Pore-Minimizing Active Ingredients

8 citations , February 2022 in “Molecules”

Asparagus racemosus root extract reduced sebum and pore size in men but not in women.

research Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2

14 citations , April 2021 in “Biology”

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

research Crystal Structure of Steroid Reductase SRD5A Reveals Conserved Steroid Reduction Mechanism

July 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

research Response to Letter: Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss

June 2017 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride's sexual side effects not caused by androgen deficiency or SRD5A inhibition.

Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza Sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances

research Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza Sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances

7 citations , January 2022 in “Plants”

Rice husk and bran extracts from the Bue Bang 3 CMU variety can potentially treat hair loss due to their antioxidant, anti-inflammatory, and anti-androgenic properties.

View more "srd5a" in research →

Community Join

5 / 37 results

community A systematic bro-science review of DHT, 5AR, neurosteroids, sexual health and 5AR inhibitors

in Research/Science 37 upvotes 3 years ago

Hair loss treatments, specifically 5AR inhibitors, can impact neurosteroids and sexual health. The effects of topical fin/dut on tissue-specific DHT levels are unclear.

community Study shows further evidence that finasteride and dutasteride take 12-18 months or more to show significant results. Do NOT give up early

in Finasteride/Dutasteride 247 upvotes 2 years ago

The conversation discusses the effectiveness of finasteride and dutasteride in treating hair loss, emphasizing that significant results often take 12-18 months or more. Dutasteride is generally considered superior, with similar or fewer side effects than finasteride, but patience is required for noticeable improvement.

community Anyone experienced weight gain on dutasteride?

in Finasteride/Dutasteride 6 upvotes 3 years ago

Dutasteride can lead to increased cholesterol and liver fat. The user is reconsidering its use due to high cholesterol and lipid levels despite a healthy lifestyle.

community Why does it seem everyone favors finasteride over dutasteride?

in Female 62 upvotes 1 year ago

The conversation discusses preferences for hair loss treatments, specifically finasteride over dutasteride. Users share personal experiences, cost considerations, FDA approval status, and potential side effects, with some switching between treatments to find what works best for them.

community Two Great Articles on NCBI That Summarize What We Actually Know About Finasteride Side Effects

in Finasteride 80 upvotes 6 years ago

The side effects of taking finasteride as a treatment for hair loss, with particular focus on its sexual and psychiatric side effects; research has indicated that there are high and low outliers in terms of prevalence of sexual side effects, but it is usually between 3-5%, while evidence of lasting sexual side effects comes from lower quality sources.

View more "srd5a" in community →