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    Glossary SRD5A3

    enzyme involved in converting testosterone to dihydrotestosterone (DHT)

    SRD5A3 stands for steroid 5 alpha-reductase 3, an enzyme that plays a crucial role in the conversion of testosterone to dihydrotestosterone (DHT), a more potent androgen. This enzyme is also involved in the biosynthesis of dolichol, which is essential for protein glycosylation, a process important for proper cellular function. Mutations in the SRD5A3 gene can lead to congenital disorders such as SRD5A3-CDG (Congenital Disorder of Glycosylation).

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    Research 30 of 432

    1. SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder Cell · 2010 · 260 citations
    2. Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: No association with female pattern hair loss identified Experimental Dermatology · 2012 · 18 citations
    3. Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2 Biology · 2021 · 14 citations
    4. 5α-reduction of epitestosterone is catalysed by human SRD5A1 and SRD5A2 and increases androgen receptor transactivation The Journal of Steroid Biochemistry and Molecular Biology · 2024 · 14 citations
    5. In Vitro and In Vivo Regulation of SRD5A mRNA Expression of Supercritical Carbon Dioxide Extract from Asparagus racemosus Willd. Root as Anti-Sebum and Pore-Minimizing Active Ingredients Molecules · 2022 · 8 citations
    6. Altered methylation pattern of the SRD5A2 gene in the cerebrospinal fluid of post-finasteride patients: a pilot study Endocrine connections · 2019 · 8 citations
    7. Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances Plants · 2022 · 7 citations
    8. Longer TA repeat but not V89L polymorphisms in the SRD5A2 gene may confer acne risk in the Chinese population Postępy Dermatologii i Alergologii · 2018 · 3 citations
    9. Exploring the clinical implications of novel SRD5A2 variants in 46,XY disorders of sex development Asian Journal of Andrology · 2024 · 2 citations
    10. Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism bioRxiv (Cold Spring Harbor Laboratory) · 2020
    11. Identification of xenobiotics interfering with 5 <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline" id="d1e152" altimg="si21.svg"> <mml:mi>α</mml:mi> </mml:math> -reductase (SRD5A2) activity Toxicology Letters · 2026
    12. SRD5A2 and emerging therapies in androgen-driven disorders Nature Reviews Urology · 2026
    13. Cloning, computational analysis and expression profiling of steroid 5 alpha-reductase 1 (SRD5A1) gene during reproductive phases and ovatide stimulation in endangered catfish, Clarias magur Scientific reports · 2023
    14. Multi-target evaluation of Korean herbal compounds against the SRD5A2 / AR / beta-catenin axis for androgenetic alopecia: Boltz-2 cofold, ChEMBL-anchored ranking, ADMET-AI 107-endpoint safety panel, and pilosebaceous single-cell atlas-constrained prioritization of Saponin Re, Emodin, and Biochanin A Zenodo (CERN European Organization for Nuclear Research) · 2026
    15. Multi-target evaluation of Korean herbal compounds against the SRD5A2 / AR / beta-catenin axis for androgenetic alopecia: Boltz-2 cofold, ChEMBL-anchored ranking, ADMET-AI 107-endpoint safety panel, and pilosebaceous single-cell atlas-constrained prioritization of Saponin Re, Emodin, and Biochanin A Zenodo (CERN European Organization for Nuclear Research) · 2026
    16. Multi-target evaluation of Korean herbal compounds against the SRD5A2 / AR / beta-catenin axis for androgenetic alopecia: Boltz-2 cofold, ChEMBL-anchored ranking, ADMET-AI 107-endpoint safety panel, and pilosebaceous single-cell atlas-constrained prioritization of Saponin Re, Emodin, and Biochanin A Zenodo (CERN European Organization for Nuclear Research) · 2026
    17. Multi-target evaluation of Korean herbal compounds against the SRD5A2 / AR / beta-catenin axis for androgenetic alopecia: Boltz-2 cofold, ChEMBL-anchored ranking, ADMET-AI 107-endpoint safety panel, and pilosebaceous single-cell atlas-constrained prioritization of Saponin Re, Emodin, and Biochanin A Open Science Framework · 2026
    18. Multi-target evaluation of Korean herbal compounds against the SRD5A2 / AR / beta-catenin axis for androgenetic alopecia: Boltz-2 cofold, ChEMBL-anchored ranking, ADMET-AI 107-endpoint safety panel, and pilosebaceous single-cell atlas-constrained prioritization of Saponin Re, Emodin, and Biochanin A Zenodo (CERN European Organization for Nuclear Research) · 2026
    19. DNMT1 targets SRD5A2 to induce mitochondrial homeostasis and EMT in urothelial cells of hypospadias Molecular Biology Reports · 2025
    20. HPLC Profiling and Insilco studies of Chochurus olitoris (Jute) Leave Fractions against Steroid 5α-Reductase 2 (SRD5α2) Biomedical Journal of Scientific & Technical Research · 2024
    21. MP09-17 METHYLATION OF SRD5A2 IN THE BLOOD AS A NOVEL BIOMARKER TO PREDICT SENSITIVITY TO 5-ARI TREATMENT 2024
    22. Bioactive metabolites of edible mushrooms efficacious against androgenic alopecia: Targeting SRD5A2 using computational approach Journal of Herbal Medicine · 2022
    23. Bioactive metabolites of edible mushrooms efficacious against androgenic alopecia: Targeting SRD5A2 using computational approach Research Square (Research Square) · 2022
    24. PD02-05 SRD5A2 EXPRESSION IS A PREDICTOR OF RESPONSE TO FINASTERIDE IN THE MTOPS TRIAL The Journal of Urology · 2023
    25. Genetic Analysis of Male Pattern Baldness and the 5α-Reductase Genes Journal of Investigative Dermatology · 1998 · 169 citations
    26. Molecular epidemiology of hypospadias: Review of genetic and environmental risk factors Birth Defects Research · 2003 · 103 citations
    27. Steroidogenesis of the testis – new genes and pathways Annales d'endocrinologie · 2014 · 70 citations
    28. Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts The Journal of Steroid Biochemistry and Molecular Biology · 2009 · 57 citations
    29. 5α-Reductase type 2 gene variant associations with prostate cancer risk, circulating hormone levels and androgenetic alopecia International Journal of Cancer · 2006 · 57 citations
    30. 5α-Reductase Type 2 Regulates Glucocorticoid Action and Metabolic Phenotype in Human Hepatocytes Endocrinology · 2015 · 54 citations