5α-Reductase Type 1 Inhibition of Oryza Sativa Bran Extract Prepared by Supercritical Carbon Dioxide Fluid

August 2011 in “ Journal of Supercritical Fluids ”

Warintorn Ruksiriwanich, Jiradej Manosroi, Masahiko Abe, Worapaka Manosroi, Aranya Manosroi

5α-reductase type 1 Oryza sativa rice bran extract supercritical carbon dioxide fluid unsaturated fatty acids linoleic acid DU-145 cell line enzyme inhibition anti-androgenic alopecia 5-alpha-reductase type 1 scCO₂ androgenic alopecia

Studysummary In this study, fraction No. 3 of Oryza sativa bran extract demonstrated high unsaturated fatty acid content and significant 5α-reductase inhibition, suggesting potential for developing anti-androgenic alopecia products.

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The 2011 study focused on the potential of Oryza sativa (rice) bran extract, prepared using supercritical carbon dioxide fluid (scCO₂), to inhibit 5α-reductase type 1, an enzyme associated with hair loss. Fraction No. 3 of the extract, which had the highest content of unsaturated fatty acids, showed significant 5α-reductase inhibition activity in DU-145 cell line tests. A strong positive correlation was found between the linoleic acid and total unsaturated fatty acid contents and the enzyme inhibition activity. The study suggests that this fraction of the O. sativa bran extract could be developed as an anti-androgenic alopecia product. The research did not involve human subjects but was conducted on cell lines.

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