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    Research 10 of 1000+

    1. The 5alpha-reductase type 1, but not type 2, gene is expressed in anagen hairs plucked from the vertex area of the scalp of hirsute women and normal individuals Brazilian Journal of Medical and Biological Research · 2003 · 17 citations
    2. Predominant expression of 5 alpha-reductase type 1 in pubic skin from normal subjects and hirsute patients. 1996 · 11 citations
    3. LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1. Proceedings of the National Academy of Sciences of the United States of America · 1993 · 53 citations
    4. Sexual dimorphism of growth plate prehypertrophic and hypertrophic chondrocytes in response to testosterone requires metabolism to dihydrotestosterone (DHT) by steroid 5‐alpha reductase type 1 Journal of Cellular Biochemistry · 2005 · 27 citations
    5. Effect of MK-386, a novel inhibitor of type 1 5 alpha-reductase, alone and in combination with finasteride, on serum dihydrotestosterone concentrations in men. The Journal of Clinical Endocrinology and Metabolism · 1996 · 6 citations
    6. Effect of MK-386, a novel inhibitor of type 1 5 alpha-reductase, alone and in combination with finasteride, on serum dihydrotestosterone concentrations in men The Journal of Clinical Endocrinology and Metabolism · 1996 · 7 citations
    7. Exercise activates the PI3K-AKT signal pathway by decreasing the expression of 5α-reductase type 1 in PCOS rats Scientific reports · 2018 · 28 citations
    8. Changes in serum free testosterone, sleep patterns, and 5‐alpha‐reductase type I activity influence changes in sebum excretion in female subjects Skin research and technology · 2014 · 10 citations
    9. Design, synthesis and biological evaluation of novel androst-3,5-diene-3-carboxylic acid derivatives as inhibitors of 5α-reductase type 1 and 2 Steroids · 2017 · 8 citations
    10. In silico screening of effective inhibitor of 5α-reductase type 1 for androgenic alopecia treatment Natural Product Research · 2021 · 1 citations
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    Community 10 of 1000+

    1. 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that? Reddit · 3 Oct 2024
    2. How come Dut doesn’t cause more brain problems than fin if it inhibits Type 1 5AR? Reddit · 26 Jun 2024
    3. 5ar Type I in the frontal hair follicles - Dutasteride Reddit · 30 Apr 2024
    4. Fun thought experiment about halting hair loss permamently Reddit · 6 May 2024
    5. Was scared to try fin and jumped straight to 2.5mg Dut? Reddit · 12 Sept 2026
    6. The truth about Dutasteride (w/ sources) Reddit · 24 Jan 2023
    7. Thoughts on this Article: Post-Finasteride and Neurological Effects Reddit · 16 Mar 2024
    8. DHT and 5AR respect post, it's importance within the brain Reddit · 3 Mar 2024
    9. Whats up with all the dutasteride destroying hair posts Reddit · 12 May 2023
    10. My story (22m, fin, min, niz, RU, dut –> part frontal hair system) Reddit · 6 May 2023
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    Learn 3 of 24

    1. Dutasteride 5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride
    2. Finasteride Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically
    3. Neem Oil Oil from the neem tree, used in traditional remedies
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