Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza Sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances

January 2022 in “ Plants ”

Chiranan Khantham, Pichchapa Linsaenkart, Tanakarn Chaitep, Pensak Jantrawut, Chuda Chittasupho, Pornchai Rachtanapun, Kittisak Jantanasakulwong, Yuthana Phimolsiripol, Sarana Rose Sommano, Chanakan Prom-u-thai, Sansanee Jamjod, Chaiwat Arjin, Korawan Sringarm, Houda Berrada, Francisco J. Barba, F.D. Carmona, Wutigri Nimlamool, Warintorn Ruksiriwanich

androgenetic alopecia BB3CMU-H BB3CMU-RB polyphenols tocopherols steroid 5α-reductase SRD5A anti-inflammatory diclofenac sodium salt AGA rice husk extract rice bran extract antioxidants vitamin E 5-alpha reductase diclofenac

TLDR Rice husk and bran extracts from the Bue Bang 3 CMU variety can potentially treat hair loss due to their antioxidant, anti-inflammatory, and anti-androgenic properties.

The study investigated the potential of extracts from the husk and bran of a local rice variety, Bue Bang 3 CMU (BB3CMU), as treatment for Androgenetic alopecia (AGA). The husk extract (BB3CMU-H) had high levels of polyphenols, contributing to its strong antioxidant activity, while the bran extract (BB3CMU-RB) was rich in tocopherols, resulting in better anti-androgenic activities through the downregulation of steroid 5α-reductase genes (SRD5A). Both extracts showed anti-inflammatory effects comparable to diclofenac sodium salt. The study concluded that the combination of BB3CMU-H and BB3CMU-RB could be utilized in cosmeceutical and pharmaceutical applications for AGA patients.

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