Effectiveness of the Combinational Treatment of Laminaria Japonica and Cistanche Tubulosa Extracts in Hair Growth

January 2015 in “ Laboratory Animal Research ”

Kyungha Shin, Tae Su Kim, Jangbeen Kyung, Dajeong Kim, Dongsun Park, Eugene Choi, Sung Pyo Lee, Woong Suk Yang, Myung-Hwa Kang, Yun-Bae Kim

From the encyclopedia

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Epidermal Growth Factor →

Vascular Endothelial Growth Factor →

Studysummary This study found that oral administration of Laminaria japonica and Cistanche tubulosa extracts may improve hair regrowth in mice, comparable to the effects of 3% Minoxidil, potentially due to their anti-inflammatory properties. Our plain-language summary of this paper — not a Tressless recommendation.

The study from 2015 examined the hair growth-promoting effects of Laminaria japonica extract (LJE) and Cistanche tubulosa extract (CTE) on male C57BL/6 mice, comparing them to the effects of 3% Minoxidil. Over 21 days, the mice were treated with these substances, and the combination of LJE and CTE at specific doses (54 mg/kg LJE plus 162 mg/kg CTE) showed synergistic effects on hair regrowth, comparable to Minoxidil. This combination enhanced enzyme activities and growth factor levels associated with hair growth, such as ALP, y-GTP, EGF, and VEGF. Additionally, the extracts demonstrated anti-inflammatory properties by reducing inflammation in a mouse model. The study concluded that the oral treatment with LJE and CTE could be an effective approach to prevent hair loss and improve alopecia, potentially due to their anti-inflammatory activities.

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Research cited in this study

18 / 18 results

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32 citations , April 1999 in “Expert Opinion on Investigational Drugs”

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Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy

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This study found that twice-daily intradermal injections of mouse epidermal growth factor in Merino sheep resulted in dose-dependent changes in wool follicles and fibres, including induction of catagen and subsequent regeneration.

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This study observed that hair regrowth in mice was irregular and delayed more in older mice, with increased enzyme activities in hair re-growing areas compared to non-growing areas.

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This report describes a case of hypertrichosis associated with minoxidil use and suggests that nearly all patients on this drug may experience this side effect.