Iris Germanica L. Rhizome-Derived Exosomes Ameliorated Dihydrotestosterone-Damaged Human Follicle Dermal Papilla Cells Through the Activation of Wnt/β-Catenin Pathway

    Mujun Kim, Jung Hyun Woo, Jinsick Kim, Min‐Ah Choi, Hee Jung Shin, Young-Seok Kim, Junoh Kim, Dong Wook Shin
    TLDR Iris-exosomes may help treat hair loss by activating hair growth pathways.
    This study examines the potential of exosomes derived from Iris germanica L. rhizomes to mitigate damage in human follicle dermal papilla cells (HFDPCs) caused by dihydrotestosterone (DHT), a major factor in androgenetic alopecia. The exosomes were found to significantly reduce oxidative stress, restore mitochondrial function, and enhance cellular processes essential for hair follicle regeneration, such as cell migration and 3D spheroid formation. These beneficial effects are mediated through the activation of the Wnt/β-catenin signaling pathway, crucial for hair growth. The findings suggest that Iris-exosomes could serve as promising plant-based therapeutic agents for hair loss treatment, although further clinical studies are necessary to confirm their efficacy.
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