Cellular Senescence: Ageing and Androgenetic Alopecia

January 2023 in “ Dermatology ”

Yong Qiong Deng, Mengxue Wang, Yuxin He, Fuming Liu, Lingna Chen, Xia Xiong

androgenetic alopecia miniaturization of hair follicles senescent cells androgen oxidative stress dermal papilla cells hair follicle stem cells senescence-associated secretory phenotype AGA DPCs HFSCs SASP

TLDR Ageing and increased senescent cells significantly contribute to common hair loss.

The review "Cellular Senescence: Ageing and Androgenetic Alopecia" explores the connection between ageing and androgenetic alopecia (AGA), the most common type of hair loss characterized by the miniaturization of hair follicles. It highlights that beyond genetic and androgen factors, ageing and the associated increase in senescent cells play a significant role in AGA. The review discusses how androgen and oxidative stress-induced senescence mechanisms contribute to AGA and suggests potential therapeutic strategies. These strategies include inhibiting the senescence of dermal papilla cells (DPCs) and hair follicle stem cells (HFSCs), removing senescent cells, and reducing the senescence-associated secretory phenotype (SASP).

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