Cellular Senescence: Ageing and Androgenetic Alopecia

January 2023 in “ Dermatology ”

Yong Qiong Deng, Mengxue Wang, Yuxin He, Fuming Liu, Lingna Chen, Xia Xiong

androgenetic alopecia miniaturization of hair follicles senescent cells androgen oxidative stress dermal papilla cells hair follicle stem cells senescence-associated secretory phenotype AGA DPCs HFSCs SASP

TLDR Ageing and increased senescent cells significantly contribute to common hair loss.

The review "Cellular Senescence: Ageing and Androgenetic Alopecia" explores the connection between ageing and androgenetic alopecia (AGA), the most common type of hair loss characterized by the miniaturization of hair follicles. It highlights that beyond genetic and androgen factors, ageing and the associated increase in senescent cells play a significant role in AGA. The review discusses how androgen and oxidative stress-induced senescence mechanisms contribute to AGA and suggests potential therapeutic strategies. These strategies include inhibiting the senescence of dermal papilla cells (DPCs) and hair follicle stem cells (HFSCs), removing senescent cells, and reducing the senescence-associated secretory phenotype (SASP).

View this study on karger.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 742 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 669 upvotes 2 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community SCUBE3 and GT20029 could be the closet thing to a cure: Hair Follicle Regeneration and Protection Against DHT

in Research/Science 15 upvotes 1 year ago

SCUBE3 and GT20029 are potential treatments for hair loss, with SCUBE3 stimulating hair growth and GT20029 protecting against DHT. A combined approach using SCUBE3, finasteride or dutasteride, and later GT20029 could provide a comprehensive treatment for androgenetic alopecia.

community Most Recent Interesting Hairloss Studies: 10% Minox vs 5% Minox / Radio Rrequency Treatment for AA / Topical Ketoconazole / PRP+Minox vs Minox vs PRP / Alopecia as a systemic disease

in Treatment 88 upvotes 4 years ago

Treatments for hair loss, such as topical minoxidil, platelet-rich plasma therapy with or without minoxidil, ketoconazole, non-abative radio frequency, natural products, finasteride and cortexolone 17 alpha propionate. The post evaluates the efficacy and safety of these treatments in various studies.

community Innovative hair loss treatment can restore 90% of lost hair

in Research/Science 889 upvotes 2 months ago

A new hair loss treatment using dermal exosomes can restore up to 90% of lost hair in mice. Users discuss potential human trials and compare it to Minoxidil and Finasteride.

community Why is dht bad for scalp hair but good for hair on the rest of body?

in Satire 109 upvotes 1 year ago

The conversation discusses why DHT (dihydrotestosterone) negatively affects scalp hair but promotes growth elsewhere on the body. Various opinions include genetic predispositions, differences in hair follicle reactions to DHT, and the potential role of Omega-3 in reducing inflammation and promoting hair health.

Related Research

4 / 4 results

research Oxidative Stress: Insights into the Pathogenesis and Treatment of Alopecia

January 2023 in “Journal of Ravishankar University”

Hair loss can be caused by stress, aging, and harmful substances that create an imbalance in the body's natural processes.

MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

research MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

18 citations, December 2020 in “Frontiers in cell and developmental biology”

miR-140-5p in certain cell vesicles helps hair growth by boosting cell proliferation.

research Relation Between Dermal Papilla Cells and Androgenetic Alopecia

January 2010 in “International Journal of Dermatology and Venereology”

Dermal papilla cells play a key role in hair loss by responding to androgens.

research Male Androgenetic Alopecia

17 citations, December 2004 in “The Journal of Men's Health & Gender”

Male pattern baldness involves hormone-related hair thinning, shorter hair, and inflammation.