Oxidative Stress: Insights into the Pathogenesis and Treatment of Alopecia
January 2023
in “
Journal of Ravishankar University
”
oxidative stress free radicals reactive oxygen species inflammation hair follicles alopecia hair loss cell death H2O2 hydrogen peroxide nitric oxide ultraviolet rays ionizing radiations endotoxin-induced inflammation photodynamic therapy cigarette smoke androgenic alopecia copper metabolism zinc metabolism redox balance oxidative injury UV rays
TLDR Hair loss can be caused by stress, aging, and harmful substances that create an imbalance in the body's natural processes.
The document "Oxidative stress: Insights into the Pathogenesis and Treatment of Alopecia" explains that environmental and cosmetic substances can generate free radicals and reactive oxygen species, causing oxidative stress. This stress can lead to inflammation, psycho-emotional stress, and influence aging, including hair follicles, resulting in alopecia or hair loss. The death of cells in the hair follicle is linked to oxidative stress mechanisms, including H2O2, nitric oxide and derivatives, ultraviolet rays, ionizing radiations, endotoxin-induced inflammation, photodynamic therapy, and cigarette smoke. In androgenic alopecia, a disrupted copper and zinc metabolism was found in patients' serum, urine, and hair, indicating increased oxidative stress. The review highlights the role of reactive oxygen species in disrupting the redox balance and causing oxidative injury, leading to androgenic alopecia.
