Resveratrol-Loaded Versatile Nanovesicle for Alopecia Therapy via Comprehensive Strategies

    Xuefei Zhang, Junjun Hao, T LU, Yating Dong, Yingying Sun, Yingjun Yu, Shuxuan Li, Shihui Yu, Haiyan Hu
    TLDR Resveratrol-loaded nanovesicles effectively promote hair growth and treat hair loss.
    The study examines the use of resveratrol-loaded nanovesicles (PPD-Lip@RES) for alopecia treatment, highlighting its potential as a superior alternative to current treatments like minoxidil and finasteride. PPD-Lip@RES enhances drug delivery, promotes hair growth, and maintains hair follicle health by addressing oxidative stress and inflammation. In vitro and in vivo experiments demonstrate its effectiveness in promoting cell proliferation, angiogenesis, and hair follicle activity, leading to improved hair regrowth and follicle health in mouse models. The treatment activates key signaling pathways and upregulates hair growth-related genes, offering a promising strategy for alopecia therapy with enhanced biological activity and reduced side effects.
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