The Impact of Oxidative Stress in Androgenic Alopecia in Women

    January 2020 in “ Postepy Dermatologii I Alergologii ”
    Anna Cwynar, Dorota Olszewska-Słonina, Rafał Czajkowski
    Image of study
    TLDR Oxidative stress plays a role in female pattern baldness, causing an imbalance between harmful and protective elements in the body.
    In a study conducted three years ago, researchers investigated the role of oxidative stress in androgenic alopecia (AGA), a common form of female pattern baldness, by comparing 12 AGA female patients with 25 healthy controls. The study found that plasma and erythrocyte malondialdehyde (MDA) levels were higher in AGA patients, suggesting the presence of oxidative stress. Additionally, ceruloplasmin (CER) levels were significantly increased in AGA patients, supporting the hypothesis of AGA as an inflammatory disease. The activity of paraoxonase 1 (PON1), an enzyme with antioxidant activity, was significantly reduced in AGA patients, which may play a role in the progression and/or development of AGA. These findings indicate a disturbance of the oxidative-antioxidant balance in AGA in women.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 64 results

      community Quit vaping/smoking = 80% less loss

      in Research/Science  235 upvotes 7 months ago
      Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  138 upvotes 9 months ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community HLT Megathread on HMI-115 (key takeaways in comments)

      in Research/Science  40 upvotes 1 year ago
      HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

      community 35% regrowth brothers and sisters! More effective than Minox and Fin?

      in Treatment  107 upvotes 6 years ago
      A double-blind clinical study that found ingestion of tocotrienols resulted in a 34.5% increase in hair regrowth compared to the placebo group, and discussion about potential side effects and cost of supplementation with vitamin E pills. The conversation noted that it may be more effective than commonly used treatments like minoxidil and finasteride.

    Similar Research

    5 / 1000+ results