The Impact of Oxidative Stress in Androgenic Alopecia in Women

In a study conducted three years ago, researchers investigated the role of oxidative stress in androgenic alopecia (AGA), a common form of female pattern baldness, by comparing 12 AGA female patients with 25 healthy controls. The study found that plasma and erythrocyte malondialdehyde (MDA) levels were higher in AGA patients, suggesting the presence of oxidative stress. Additionally, ceruloplasmin (CER) levels were significantly increased in AGA patients, supporting the hypothesis of AGA as an inflammatory disease. The activity of paraoxonase 1 (PON1), an enzyme with antioxidant activity, was significantly reduced in AGA patients, which may play a role in the progression and/or development of AGA. These findings indicate a disturbance of the oxidative-antioxidant balance in AGA in women.