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GlossaryParaoxonase 1 (PON1)

enzyme that breaks down toxic chemicals and protects cells

Paraoxonase 1 (PON1) is an enzyme that plays a crucial role in breaking down certain toxic chemicals, including pesticides and nerve agents, and also helps protect cells from oxidative damage. It is associated with high-density lipoprotein (HDL) in the blood and contributes to cardiovascular health by preventing the oxidation of low-density lipoprotein (LDL), which can lead to atherosclerosis.

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research HSL Attenuates Follicular Oxidative Stress and Enhances Hair Growth in ob/ob Mice

6 citations, October 2013 in “Plastic and Reconstructive Surgery – Global Open”

HSL treatment speeds up hair growth and reduces oxidative stress in hair follicles of ob/ob mice.

research The Role of Reactive Oxygen Species in the Pathogenesis of Alopecia Areata: A Systematic Review and Meta-Analysis

January 2025 in “Skin Pharmacology and Physiology”

Oxidative stress contributes to alopecia areata, suggesting antioxidant treatments might help.

research The Impact of Oxidative Stress in Androgenic Alopecia in Women

7 citations, January 2020 in “Postepy Dermatologii I Alergologii”

Oxidative stress plays a role in female pattern baldness, causing an imbalance between harmful and protective elements in the body.

research Oxidative Stress and Antioxidant Markers in Patients with Alopecia Areata: A Comparative Cross-Sectional Study

3 citations, July 2022 in “Indian journal of dermatology, venereology, and leprology”

Patients with alopecia areata have higher oxidative stress and lower antioxidant levels.

research Paraoxonase 1 (PON1) L55M and Q192R Polymorphisms, Lipid Profiles, and Psoriasis

April 2017 in “Journal of Investigative Dermatology”

The PON1 192R gene variant is linked to a higher risk of psoriasis and heart disease in Western Mexico.

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