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GlossaryParaoxonase 1 (PON1)

enzyme that breaks down toxic chemicals and protects cells

Paraoxonase 1 (PON1) is an enzyme that plays a crucial role in breaking down certain toxic chemicals, including pesticides and nerve agents, and also helps protect cells from oxidative damage. It is associated with high-density lipoprotein (HDL) in the blood and contributes to cardiovascular health by preventing the oxidation of low-density lipoprotein (LDL), which can lead to atherosclerosis.

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research Investigation of Paraoxonase Enzyme Polymorphism in Patients with Alopecia Areata

March 2016 in “West Indian medical journal”

There is no significant link between alopecia areata and the PON1 enzyme polymorphisms studied.

research Evaluation of Paraoxonase 1 Serum Level in Male Androgenetic Alopecia Patients

October 2023 in “Benha Journal of Applied Sciences”

Men with male pattern baldness have lower levels of the antioxidant PON1.

research The Role of Reactive Oxygen Species in the Pathogenesis of Alopecia Areata: A Systematic Review and Meta-Analysis

January 2025 in “Skin Pharmacology and Physiology”

Oxidative stress contributes to alopecia areata, suggesting antioxidant treatments might help.

research The Impact of Oxidative Stress in Androgenic Alopecia in Women

7 citations , January 2020 in “Postepy Dermatologii I Alergologii”

Oxidative stress plays a role in female pattern baldness, causing an imbalance between harmful and protective elements in the body.

research Oxidative Stress and Antioxidant Markers in Patients with Alopecia Areata: A Comparative Cross-Sectional Study

3 citations , July 2022 in “Indian journal of dermatology, venereology, and leprology”

Patients with alopecia areata have higher oxidative stress and lower antioxidant levels.

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