Paraoxonase 1 (PON1) L55M and Q192R Polymorphisms, Lipid Profiles, and Psoriasis

The document reports on a case-control study that investigated the association between Paraoxonase 1 (PON1) polymorphisms, lipid profiles, and psoriasis. The study included 100 patients with psoriasis and 100 healthy controls from Western Mexico. The researchers focused on two PON1 polymorphisms: L55M and Q192R. They found that the PON1 55M allele was not associated with psoriasis, but the PON1 192R allele was significantly associated with the condition. Individuals with the 192R allele had higher very-low-density lipoprotein (VLDL) cholesterol and Castelli index, but lower high-density lipoprotein (HDL) cholesterol compared to controls. The homozygous RR phenotype was strongly associated with psoriasis. The study concluded that the PON1 192R allele is a risk factor for psoriasis in the Western Mexico population and that carriers of this allele are more susceptible to cardiovascular diseases due to oxidative stress.