Dietary Fat- and Obesity-Sensitive Dermal Adipocyte PKCβ Induction and Inflammation Cross-Talk
April 2017
in “
Journal of Investigative Dermatology
”
protein kinase C beta PKCβ dermal adipocytes high-fat diet inflammatory markers PKCβ deficiency dermal inflammation skin hair texture skin hair density dietary lipids dermal inflammatory microenvironment floxed PKCβ mouse model adipose-specific contributions immune responses wound healing scarring hair-follicle growth PKC beta PKC beta deficiency inflammation skin hair dietary fats inflammatory environment mouse model immune system wound repair scar formation hair growth
TLDR Eating a lot of fat increases PKCβ and inflammation in skin fat cells, which affects skin and hair health.
The document presents several abstracts from a journal, but the specific abstract requested for summarization discusses the role of protein kinase C beta (PKCβ) in diet- and obesity-induced changes in dermal adipocytes and their impact on skin health. The study found that a high-fat diet strongly induces the expression of PKCβ and inflammatory markers in adipocytes in a time-dependent manner. PKCβ deficiency was associated with improvements in dermal adipocyte inflammation, as well as the texture and density of skin hair. The research suggests that PKCβ is a key transducer of dietary lipids and plays a critical role in modulating the dermal inflammatory microenvironment. The study also mentions the generation of a floxed PKCβ mouse model to further investigate the adipose-specific contributions of the diet-adipocyte PKCβ/inflammation axis to immune responses, wound healing, scarring, and hair-follicle growth. The number of participants or subjects in the study is not mentioned in the abstract.
