Dietary Fat- and Obesity-Sensitive Dermal Adipocyte PKCβ Induction and Inflammation Cross-Talk
April 2017
in “
Journal of Investigative Dermatology
”
protein kinase C beta PKCβ dermal adipocytes high-fat diet inflammatory markers PKCβ deficiency dermal inflammation skin hair texture skin hair density dietary lipids dermal inflammatory microenvironment floxed PKCβ mouse model adipose-specific contributions immune responses wound healing scarring hair-follicle growth PKC beta PKC beta deficiency inflammation skin hair dietary fats inflammatory environment mouse model immune system wound repair scar formation hair growth
Studysummary This study suggests that PKCß plays a critical role in modulating the dermal inflammatory microenvironment in response to dietary lipids in mice.
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The document presents several abstracts from a journal, but the specific abstract requested for summarization discusses the role of protein kinase C beta (PKCβ) in diet- and obesity-induced changes in dermal adipocytes and their impact on skin health. The study found that a high-fat diet strongly induces the expression of PKCβ and inflammatory markers in adipocytes in a time-dependent manner. PKCβ deficiency was associated with improvements in dermal adipocyte inflammation, as well as the texture and density of skin hair. The research suggests that PKCβ is a key transducer of dietary lipids and plays a critical role in modulating the dermal inflammatory microenvironment. The study also mentions the generation of a floxed PKCβ mouse model to further investigate the adipose-specific contributions of the diet-adipocyte PKCβ/inflammation axis to immune responses, wound healing, scarring, and hair-follicle growth. The number of participants or subjects in the study is not mentioned in the abstract.
