Metabolic Syndrome and Skin Diseases

November 2019 in “ Frontiers in Endocrinology ”

Yu Hu, Yun Zhu, Ni Lian, Min Chen, Andrzej Bartke, Rong Yuan

androgenetic alopecia insulin resistance chronic inflammation adipokines Adipose-Derived Mesenchymal Stem Cells ADMSCs hair loss stem cell therapy

Studysummary This review discusses the links between metabolic syndrome and various skin diseases, exploring shared mechanisms such as insulin resistance and inflammation, but reports no new clinical results. Our plain-language summary of this paper — not a Tressless recommendation.

The document "Metabolic Syndrome and Skin Diseases" from November 20, 2019, explored the link between Metabolic Syndrome (MetS) and various skin conditions, including psoriasis, acne vulgaris, hidradenitis suppurativa, androgenetic alopecia, acanthosis nigricans, and atopic dermatitis. MetS, characterized by conditions like high blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol levels, was found to be associated with these skin diseases. The document suggested that insulin resistance, chronic inflammation, and altered secretion of adipokines could be the common mechanisms underlying MetS and these skin conditions. The document also discussed the potential of Adipose-Derived Mesenchymal Stem Cells (ADMSCs) therapy in treating MetS and related skin diseases. However, the exact mechanisms remained unclear, and more research was needed. The document did not provide the exact number of participants in the study.

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17 / 17 results

research Association of Androgenetic Alopecia with Metabolic Syndrome: A Case-Control Study on 100 Patients in a Tertiary Care Hospital in South India

9 citations , January 2018 in “Indian Journal of Endocrinology and Metabolism”

This study found that patients with androgenetic alopecia had a higher prevalence of metabolic syndrome compared to healthy controls.

research Gynecologic and Andrologic Dermatology and the Metabolic Syndrome

14 citations , September 2017 in “Clinics in Dermatology”

This study highlights that lower testosterone in men and higher testosterone in women are linked to increased risks of metabolic syndrome and type 2 diabetes, with associated skin diseases indicating potential cardiovascular complications.

research Acanthosis Nigricans and the Metabolic Syndrome

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This article reviews the clinical and histological features of acanthosis nigricans and its associations with insulin resistance and other conditions, but highlights the need for more research on its classification, severity assessment, and treatment options.

research Repeal And Replace: Adipocyte Regeneration In Wound Repair

22 citations , April 2017 in “Cell Stem Cell”

This study found that myofibroblasts can be reprogrammed to generate lipid-filled adipocytes in large skin wounds, potentially providing a new source of adipogenic progenitor cells for regeneration.

research Androgenetic Alopecia: A Review

153 citations , March 2017 in “Endocrine”

This review examines recent advances in understanding the pathophysiology and molecular mechanisms of androgenetic alopecia, highlighting two major genetic risk loci, but does not report new clinical findings.

research Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging

132 citations , January 2017 in “International Journal of Molecular Sciences”

This review explores how adipose-derived stem cells contribute to skin homeostasis and highlights recent advances in their clinical applications in dermatology, but it reports no new clinical results.

research Sex Hormones and Acne: The Role of the Skin as an Endocrine Organ

76 citations , October 2016 in “Clinics in dermatology”

This review discusses the hormonal and genetic factors influencing acne development, emphasizing the role of androgens and insulin signaling but reports no new clinical results.

research Association of Metabolic Syndrome With Female Pattern Hair Loss in Women: A Case-Control Study

21 citations , April 2016 in “International Journal of Dermatology”

This study found a significant association between female pattern hair loss and metabolic syndrome in Egyptian women, with waist circumference and hypertension particularly linked to the severity of hair loss.

research Benign Prostatic Hyperplasia, Metabolic Syndrome, and Androgenic Alopecia: Is There a Possible Relationship?

7 citations , February 2016 in “Arab journal of urology”

This study found that patients with androgenetic alopecia had a higher incidence of metabolic syndrome and benign prostatic hyperplasia compared to those without the condition.

Skin Expression of Mammalian Target of Rapamycin and Forkhead Box Transcription Factor O1, and Serum Insulin-Like Growth Factor-1 in Patients with Acne Vulgaris and Their Relationship with Diet

research Skin Expression of Mammalian Target of Rapamycin and Forkhead Box Transcription Factor O1, and Serum Insulin-Like Growth Factor-1 in Patients with Acne Vulgaris and Their Relationship with Diet

93 citations , January 2016 in “British Journal of Dermatology”

This study found that patients with acne vulgaris had higher serum IGF-1 levels and more intense FoxO1 and mTOR expression than controls, suggesting their role in acne pathogenesis.

research Metabolic Syndrome in Androgenic Alopecia

16 citations , January 2016 in “Indian Journal of Dermatology, Venereology and Leprology”

This study found that men with early-onset androgenic alopecia had a higher prevalence of metabolic syndrome compared to controls without the condition.

research Androgenetic Alopecia as an Indicator of Metabolic Syndrome and Cardiovascular Risk

13 citations , November 2015 in “Blood Pressure”

This study found that early-onset androgenetic alopecia, especially with a vertex pattern, may be an independent risk factor for cardiovascular disease and metabolic syndrome in men.

research Mechanistic Target of Rapamycin (mTOR) Expression Is Increased in Acne Patients' Skin

74 citations , October 2015 in “Experimental Dermatology”

This study found that mTOR gene expression was significantly increased and S6K1 activation was observed in skin samples from acne patients compared to healthy controls, suggesting mTORC1's involvement in acne pathogenesis.

research Is There Really a Relationship Between Androgenetic Alopecia and Metabolic Syndrome?

15 citations , January 2015 in “Dermatology Research and Practice”

This study found no significant association between androgenetic alopecia and metabolic syndrome, though systolic blood pressure was higher in the alopecia group compared to controls.

research Adipocytes in Skin Health and Disease

77 citations , March 2014 in “Cold Spring Harbor Perspectives in Medicine”

This research abstract provides no results, focusing on the equal contributions of the authors in the field of molecular, cellular, and developmental biology from Yale University.

research Androgenetic Alopecia, Metabolic Syndrome, and Insulin Resistance: Is There Any Association? A Case-Control Study

34 citations , January 2014 in “Indian Dermatology Online Journal”

This study supports evaluating metabolic syndrome and insulin resistance in young males with advanced androgenic alopecia to potentially reduce future cardiovascular and type 2 diabetes risks.

research Association of Androgenetic Alopecia with Metabolic Syndrome in Men: A Community-Based Survey

69 citations , April 2010 in “British Journal of Dermatology”

This study found a significant association between androgenetic alopecia and metabolic syndrome, highlighting high-density lipoprotein cholesterol as a particularly important factor.