Metabolic Syndrome and Skin Diseases

November 2019 in “ Frontiers in Endocrinology ”

Yu Hu, Yun Zhu, Ni Lian, Min Chen, Andrzej Bartke, Rong Yuan

androgenetic alopecia insulin resistance chronic inflammation adipokines Adipose-Derived Mesenchymal Stem Cells ADMSCs hair loss stem cell therapy

TLDR Metabolic Syndrome is linked to several skin conditions, and stem cell therapy might help treat them.

The document "Metabolic Syndrome and Skin Diseases" from November 20, 2019, explored the link between Metabolic Syndrome (MetS) and various skin conditions, including psoriasis, acne vulgaris, hidradenitis suppurativa, androgenetic alopecia, acanthosis nigricans, and atopic dermatitis. MetS, characterized by conditions like high blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol levels, was found to be associated with these skin diseases. The document suggested that insulin resistance, chronic inflammation, and altered secretion of adipokines could be the common mechanisms underlying MetS and these skin conditions. The document also discussed the potential of Adipose-Derived Mesenchymal Stem Cells (ADMSCs) therapy in treating MetS and related skin diseases. However, the exact mechanisms remained unclear, and more research was needed. The document did not provide the exact number of participants in the study.

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research Association of Androgenetic Alopecia with Metabolic Syndrome: A Case-Control Study on 100 Patients in a Tertiary Care Hospital in South India

9 citations , March 2018 in “Indian Journal of Endocrinology and Metabolism”

research Gynecologic and Andrologic Dermatology and the Metabolic Syndrome

14 citations , January 2018 in “Clinics in Dermatology”

Skin diseases linked to insulin resistance should be managed to prevent diabetes and reduce heart disease risk.

research Acanthosis Nigricans and the Metabolic Syndrome

30 citations , January 2018 in “Clinics in Dermatology”

Acanthosis nigricans is a skin condition that may indicate a higher risk for insulin resistance and type 2 diabetes, and more research is needed to understand and treat it.

research Repeal And Replace: Adipocyte Regeneration In Wound Repair

22 citations , April 2017 in “Cell Stem Cell”

Skin wounds can create fat cells that help regenerate hair follicles, with BMP signaling playing a crucial role in this process.

research Androgenetic Alopecia: A Review

153 citations , March 2017 in “Endocrine”

Male pattern baldness involves genetics, hormones, and needs better treatments.

research Sex Hormones and Acne: The Role of the Skin as an Endocrine Organ

76 citations , March 2017 in “Clinics in dermatology”

Sex hormones, especially androgens, play a key role in causing acne.

research Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging

132 citations , January 2017 in “International Journal of Molecular Sciences”

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

research Metabolic Syndrome in Androgenic Alopecia

16 citations , July 2016 in “Indian Journal of Dermatology, Venereology and Leprology”

research Androgenetic Alopecia as an Indicator of Metabolic Syndrome and Cardiovascular Risk

13 citations , May 2016 in “Blood Pressure”

Hair loss may indicate higher heart risk and metabolic issues.

research Skin Expression of Mammalian Target of Rapamycin and Forkhead Box Transcription Factor O1, and Serum Insulin-Like Growth Factor-1 in Patients with Acne Vulgaris and Their Relationship with Diet

93 citations , April 2016 in “British Journal of Dermatology”

Eating a high-glycemic diet may worsen acne by increasing certain protein levels and expressions in the skin.

research Association of Metabolic Syndrome With Female Pattern Hair Loss in Women: A Case-Control Study

21 citations , April 2016 in “International Journal of Dermatology”

Metabolic syndrome linked to female hair loss; waist size and high blood pressure important factors.

research Benign Prostatic Hyperplasia, Metabolic Syndrome, and Androgenic Alopecia: Is There a Possible Relationship?

7 citations , February 2016 in “Arab journal of urology”

People with early hair loss may have a higher chance of enlarged prostate and metabolic syndrome, so they should be checked for urinary and metabolic issues.

research Mechanistic Target of Rapamycin (mTOR) Expression Is Increased in Acne Patients' Skin

74 citations , December 2015 in “Experimental Dermatology”

Acne patients have higher levels of mTOR in their skin, which could be linked to future metabolic disease.

research Is There Really a Relationship Between Androgenetic Alopecia and Metabolic Syndrome?

15 citations , November 2015 in “Dermatology Research and Practice”

No clear link between hair loss and metabolic syndrome, but some differences in blood pressure and glucose levels.

research Androgenetic Alopecia, Metabolic Syndrome, and Insulin Resistance: Is There Any Association? A Case-Control Study

34 citations , July 2014 in “Indian Dermatology Online Journal”

Hair loss linked to metabolic issues and insulin resistance; early assessment may reduce future health risks.

research Adipocytes in Skin Health and Disease

77 citations , March 2014 in “Cold Spring Harbor Perspectives in Medicine”

Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.

research Association of Androgenetic Alopecia with Metabolic Syndrome in Men: A Community-Based Survey

69 citations , August 2010 in “British Journal of Dermatology”

Balding men, especially young ones, may have higher risk of heart issues and diabetes; check cholesterol levels.