The Roles of WNT Signaling Pathways in Skin Development and Mechanical-Stretch-Induced Skin Regeneration

The review article discusses the critical roles of WNT signaling pathways in skin development, wound healing, and mechanical-stretch-induced skin regeneration. It highlights how WNT signaling regulates cellular processes such as cell proliferation, stem cell maintenance, and tissue homeostasis, with a particular emphasis on the canonical WNT/β-catenin pathway's role in hair follicle formation and skin regeneration. The review also explores the regulation of WNT signaling by inhibitors like DKK and SFRP. Understanding these mechanisms could significantly advance clinical treatments for skin-related diseases. Further research is needed to confirm these effects in human skin and to understand the detailed mechanisms involved.