Involvement of Wnt, Eda, and Shh at Defined Stages of Sweat Gland Development

    September 2014 in “ Development ”
    Chang‐Yi Cui, Mingzhu Yin, Jian Sima … David Schlessinger
    Studysummary In this study, mouse sweat gland development relied on a regulatory sequence initiated by Wnt/β-catenin signaling, and disruptions in Wnt, Eda, or Shh pathways led to distinct developmental failures.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on dev.biologists.org →
    Discuss this study in the Community →

    Research cited in this study 12

    1. Label Retaining Cells with Myoepithelial Characteristics from the Proximal Acinar Region Define Stem Cells in the Sweat Gland PLoS ONE · 2013
    2. Identification of Stem Cell Populations in Sweat Glands and Ducts Reveals Roles in Homeostasis and Wound Repair Cell · 2012
    3. Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation Development · 2012
    4. Epigen Transgenic Mice Develop Enlarged Sebaceous Glands Journal of Investigative Dermatology · 2009
    5. Ectodysplasin Signaling in Cutaneous Appendage Development: Dose, Duration, and Diversity ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2009
    6. TNF Superfamily in Skin Appendage Development Cytokine & growth factor reviews · 2008
    7. The Wnt Inhibitor, Dickkopf 4, Is Induced by Canonical Wnt Signaling During Ectodermal Appendage Morphogenesis Developmental biology · 2007
    8. Scratching the Surface of Skin Development Nature · 2007
    9. Edar Signaling in the Control of Hair Follicle Development ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2005
    10. Morpho-Regulation of Ectodermal Organs ˜The œAmerican journal of pathology · 2004
    11. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    12. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999