Dermal Papilla Regulation of Hair Growth and Pigmentation

    Jamien Lim, Krystle Joy Ng, Carlos Clavel
    Image of study
    TLDR Dermal papilla cells are key for hair growth and color, influencing hair type and size, and their interaction with stem cells could help treat hair loss and color disorders.
    The document from 2019 explores the critical role of dermal papilla (DP) cells in hair growth and pigmentation, emphasizing their function as a signaling hub throughout the hair follicle cycle. It underscores the importance of the interaction between DP cells and stem cells for hair follicle morphogenesis and regeneration, with a focus on the Wnt and BMP signaling pathways. The paper reveals that DP cell numbers are influential in determining hair type and size and that DP cells exhibit heterogeneity, which may lead to the formation of microniches with distinct roles in hair follicle development. The document also discusses the interaction between DP cells and melanocyte stem cells (MSCs) for hair pigmentation, detailing the melanogenesis pathway and the factors influencing melanocyte behavior. It suggests that understanding DP cell dynamics and their cross-signaling with melanocytes could offer new avenues for treating hair pigmentation disorders and hair loss, with 3D spheroid cultures and enriched media being potential methods for maintaining DP hair induction capacity in vitro.
    Discuss this study in the Community →

    Research cited in this study

    34 / 34 results

    Related Community Posts Join

    6 / 1000+ results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Novel effect of sildenafil (cialis) on hair growth

      in Research/Science  21 upvotes 2 years ago
      Sildenafil (Viagra) shows potential for hair growth by enhancing dermal papilla cell proliferation and stimulating perifollicular vessel formation. Users discuss the possibility of using Cialis (tadalafil) similarly, noting its benefits and side effects.

      community Vitamin C and hair growth PH levels

      in Product  34 upvotes 2 years ago
      The conversation is about using vitamin C and Magnesium L-Threonate for hair growth by reducing DHT binding to dermal papilla cells. The original post about vitamin C's pH levels and sebum control was possibly removed by a moderator.

    Related Research

    4 / 4 results