An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin

    August 2015 in “ Developmental cell ”
    Rachel Sennett, Zichen Wang, Ame ́ lie Rezza, Laura Grisanti, Nataly Roitershtein, Cristina Sicchio, Ka Wai Mok, Nicholas Heitman, Carlos Clavel, Avi Ma’ayan, Michael Rendl
    TLDR The study identified unique genes in hair follicle cells and their environment, suggesting these genes help organize cells for hair growth.
    The study provided a comprehensive transcriptome analysis of embryonic hair follicle progenitors and their niche, identifying key gene expression profiles and signaling pathways, such as Wnt, Shh, and Fgf, crucial for hair follicle development. Researchers used RNA-sequencing to analyze eight isolated embryonic skin cell populations, identifying over 7,500 differentially expressed genes and defining 1,728 cell type-specific signature genes. The findings highlighted the importance of axon guidance signaling in dermal condensate cells and suggested continuity in gene function from development to maturity. The data, shared via an interactive web database, offered valuable insights into the molecular mechanisms driving hair follicle morphogenesis and skin development, potentially aiding future studies on hair growth regulation and regenerative medicine.
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