An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin

    August 2015 in “ Developmental cell ”
    Rachel Sennett, Zichen Wang, Ame ́ lie Rezza, Laura Grisanti, Nataly Roitershtein, Cristina Sicchio, Ka Wai Mok, Nicholas Heitman, Carlos Clavel, Avi Ma’ayan, Michael Rendl
    TLDR The study identified unique genes in hair follicle cells and their environment, suggesting these genes help organize cells for hair growth.
    The study provided a comprehensive transcriptome analysis of embryonic hair follicle progenitors and their niche, identifying key gene expression profiles and signaling pathways, such as Wnt, Shh, and Fgf, crucial for hair follicle development. Researchers used RNA-sequencing to analyze eight isolated embryonic skin cell populations, identifying over 7,500 differentially expressed genes and defining 1,728 cell type-specific signature genes. The findings highlighted the importance of axon guidance signaling in dermal condensate cells and suggested continuity in gene function from development to maturity. The data, shared via an interactive web database, offered valuable insights into the molecular mechanisms driving hair follicle morphogenesis and skin development, potentially aiding future studies on hair growth regulation and regenerative medicine.
    Discuss this study in the Community →

    Research cited in this study

    14 / 14 results

    Related Community Posts Join

    6 / 1000+ results

      community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

      in Research/Science  92 upvotes 3 years ago
      The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

      community My Theory Of Androgenic Alopecia

      in Research/Science  17 upvotes 2 weeks ago
      Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

      community Opinions on Scalp fibrosis and DHT?

      in Research/Science  9 upvotes 3 years ago
      The conversation discusses the theory that scalp fibrosis contributes to male pattern baldness (MPB) by increasing DHT concentration, and mentions treatments like Minoxidil. The user seeks opinions on the theory and the effectiveness of scalp massages.

      community Hair theory Scar tissue and Verteporfin

      in Chat  25 upvotes 1 year ago
      A user suggests that deeper microneedling with Verteporfin injections might help regrow hair in areas with scar tissue, alongside a DHT blocker. Another user explains that hair loss might be due to reduced Wnt/β-Catenin signaling and suggests that treatments like Minoxidil, Finasteride, and microneedling could potentially reverse it.

    Similar Research

    5 / 1000+ results