Early Inductive Events in Ectodermal Appendage Morphogenesis

January 2014 in “ Seminars in cell & developmental biology ”

Leah C. Biggs, Marja L. Mikkola

TLDR Early development of hair, teeth, and glands involves specific signaling pathways and cellular interactions.

The document reviewed the early stages of development for ectodermal appendages such as hair follicles, teeth, and mammary glands, focusing on the induction, placode, and bud stages. It summarized molecular and cellular processes identified through mouse mutant analysis and reevaluated classic epithelial–mesenchymal recombination experiments with current molecular insights. Emphasis was placed on signaling pathways mediating tissue interactions and their impact on cellular behavior shaping the developing organs.

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102 citations , August 2008 in “Genes & Development”

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