Sostdc1 Defines the Size and Number of Skin Appendage Placodes

February 2012 in “ Developmental biology ”

Katja Maria Närhi, Mark Tümmers, Laura Ahtiainen, Nobuyuki Itoh, Irma Thesleff, Marja L. Mikkola

Sostdc1 hair follicles vibrissae hair placodes Wnt/β-catenin signaling mammary glands nipple epidermis whiskers hair buds Wnt signaling

Studysummary This study found that the absence of Sostdc1 in mice alters mammary gland and hair follicle development, particularly by increasing vibrissae numbers and causing unusual nipple-like structures.

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The study investigated the role of Sostdc1 in the development of mammary glands and hair follicles in mice, revealing that Sostdc1-null mice had increased numbers and sizes of vibrissae and other muzzle hair follicles, as well as larger primary hair placodes. Sostdc1 was crucial for preventing hair follicle formation in the normally hairless nipple epidermis, leading to extra nipple-like protrusions in its absence. The findings suggested that Sostdc1 primarily functioned by attenuating Wnt/β-catenin signaling, thereby regulating the spatial organization and number of skin appendages.

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