The Origins of Skin Diversity: Lessons From Dermal Fibroblasts

The review "The origins of skin diversity: lessons from dermal fibroblasts" explores how dermal fibroblasts contribute to skin diversity, development, and disease. Dermal fibroblasts originate from different embryonic sources and are influenced by Wnt/β-catenin signaling, which is crucial for their specification and differentiation. These cells play a significant role in forming skin appendages like hair follicles, with their heterogeneity influenced by positional cues and interactions with epithelial cells. The review highlights the potential for targeting fibroblasts in therapeutic strategies for skin disorders and emphasizes the need for further research into the molecular mechanisms and epigenetic regulators involved in skin patterning and hair growth. Advances in genetic tools and single-cell RNA sequencing are enhancing the understanding of fibroblast behavior and differentiation.