Platelet-Rich Plasma and Adipose-Derived Stem Cell Therapy in the Treatment of Genital Lichen Sclerosus: A Comprehensive Review

    November 2023 in “ International Journal of Molecular Sciences ”
    Alessia Paganelli, Luca Contu, Alessandra Grazia Condorelli, Elena Ficarelli, Alfonso Motolese, Roberto Paganelli, Alberico Motolese
    TLDR PRP and ADSC therapies show promise in improving symptoms of genital lichen sclerosus with minimal side effects.
    This comprehensive review examines the use of platelet-rich plasma (PRP) and adipose-derived stem cells (ADSCs) as regenerative therapies for genital lichen sclerosus (LS), a chronic inflammatory condition affecting the genital area. Both PRP and ADSCs have shown promising results in improving LS-related symptoms such as itching, burning, and dyspareunia, while also allowing many patients to reduce or stop using topical corticosteroids. PRP promotes tissue regeneration and immune modulation, while ADSCs contribute through their plasticity and secretion of trophic factors. The therapies are generally safe, with minimal adverse effects. Combining PRP and ADSCs may offer a synergistic benefit, particularly in early-stage LS. Although current findings are encouraging, further research, including randomized controlled trials, is needed to fully understand their potential and mechanisms.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 108 results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Thoughts on platelet-rich plasma therapy

      in Treatment  3 upvotes 1 year ago
      Platelet-rich plasma (PRP) therapy for hair loss is expensive, painful, and often ineffective, with mixed reviews on its benefits. Alternatives like minoxidil, finasteride, and hair transplants are suggested as more reliable options.

      community Platelet rich plasma treatment

      in Treatment  6 upvotes 1 year ago
      A 27-year-old male experienced rapid hair loss after dengue fever, which activated a balding gene. The doctor suggested platelet-rich plasma treatment for hair regrowth.

      community platelet rich plasma experiences/thoughts?

      in Treatment  3 upvotes 3 years ago
      Hair loss discussion includes treatments like Minoxidil, finasteride, and RU58841. Platelet rich plasma treatment is considered expensive but cheaper than hair transplant.

    Similar Research

    5 / 1000+ results