Platelet-Rich Plasma and Adipose-Derived Stem Cell Therapy in the Treatment of Genital Lichen Sclerosus: A Comprehensive Review

    November 2023 in “ International Journal of Molecular Sciences ”
    Alessia Paganelli, Luca Contu, Alessandra Grazia Condorelli, Elena Ficarelli, Alfonso Motolese, Roberto Paganelli, Alberico Motolese
    TLDR PRP and ADSC therapies show promise in improving symptoms of genital lichen sclerosus with minimal side effects.
    This comprehensive review evaluates the potential of Platelet-Rich Plasma (PRP) and Adipose-Derived Stem Cell (ADSC) therapy in treating genital Lichen Sclerosus (LS), a chronic inflammatory skin condition. PRP, rich in growth factors, and ADSCs, known for their regenerative capabilities, have shown promise in alleviating LS symptoms such as itching, burning, and dyspareunia, while reducing reliance on topical corticosteroids. The therapies are noted for their safety and minimal adverse effects, such as mild, transient pain and swelling. A combination of PRP and ADSCs is particularly effective in early-stage LS, offering a synergistic approach. Data from studies involving 526 patients support the potential of these therapies to improve quality of life, though further research is needed to fully understand their long-term efficacy and mechanisms. Despite promising results, the review emphasizes the need for more extensive clinical trials to establish standardized protocols and confirm the treatments' efficacy and safety.
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