Platelet-Rich Plasma in Dermatology: Cellular and Molecular Mechanisms of Action

December 2023 in “ Biomedicines ”

Denisa Vladulescu, Lucian G. Scurtu, Anca Angela Simionescu, Francesca Frîncu, Mihaela Popescu, Olga Simionescu

platelet-rich plasma PRP angiogenesis hair follicle cell proliferation anagen phase melanin synthesis collagen production melanocyte regeneration cellular proliferation matrix formation inflammation regulation tissue remodeling

Studysummary This review discusses the mechanisms and potential benefits of platelet-rich plasma therapy for various skin conditions and reports no new clinical findings.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

Platelet-Rich Plasma (PRP) therapy in dermatology shows significant promise due to its regenerative effects and favorable safety profile. It is particularly effective in treating hair loss, promoting hair growth by enhancing angiogenesis, hair follicle cell proliferation, and prolonging the anagen phase. PRP also benefits skin conditions like melasma, vitiligo, and lichen sclerosus by reducing melanin synthesis, stimulating collagen production, and promoting melanocyte regeneration. The therapy's mechanisms include cellular proliferation, matrix formation, inflammation regulation, and tissue remodeling. While PRP's efficacy is well-supported, further randomized clinical trials are needed to fully understand and optimize its use in dermatology.

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26 / 26 results

research Efficacy of Platelet-Rich Plasma Therapy in Oral Lichen Planus: A Systematic Review

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1 citations , November 2022 in “Journal of Dermatological Treatment”

This review discusses the use of platelet-rich plasma for various dermatologic conditions but reports inconsistent evidence and a lack of standardized protocols; patients often report high satisfaction despite mixed clinical outcomes.

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5 citations , March 2022 in “Frontiers in Medicine”

This review analyzed 17 recent clinical trials on platelet-rich plasma for androgenetic alopecia but reports no new clinical results; the authors seek a consensus on optimal PRP use.

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18 citations , March 2022 in “Drug design, development and therapy”

This review examines the definition, classification, mechanism, clinical efficacy for hair regrowth, and potential adverse effects of platelet rich plasma, but does not present new experimental results.

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5 citations , August 2021 in “Clinics in dermatology”

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research Platelet-Rich Plasma and Cell Therapy

11 citations , May 2021 in “Dermatologic clinics”

This review discusses platelet-rich plasma and cell-based therapies for hair loss, noting promising results but emphasizing the need for standardization and robust trials to confirm their efficacy.

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848 citations , October 2020 in “International Journal of Molecular Sciences”

This review discusses the potential of platelet-rich plasma applications in regenerative medicine and explores recent progress and challenges in translating non-clinical PRP findings into human treatments, but reports no new clinical results.

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15 citations , October 2020 in “Journal of Investigative Dermatology Symposium Proceedings”

This review discusses the potential use of platelet-rich plasma for treating alopecia areata but reports no new experimental findings, noting the need for standardized protocols and larger studies to evaluate its efficacy.

research Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020

134 citations , October 2020 in “Preprints.org”

This review discusses recent advancements in platelet-rich plasma therapies for tissue repair and regenerative medicine, but reports no new clinical results, highlighting a need for translating research into human clinical protocols.

Comparative Evaluation of the Clinical Efficacy of PRP Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

research Comparative Evaluation of the Clinical Efficacy of PRP Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

13 citations , September 2020 in “International Journal of Molecular Sciences”

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research Progress in the Use of Platelet-Rich Plasma in Aesthetic and Medical Dermatology

3 citations , August 2020 in “PubMed”

This review discusses the potential efficacy and applications of platelet-rich plasma in dermatology, highlighting its use in various skin conditions but reporting no new clinical results; the authors call for standardization of preparation and treatment methods.

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research Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

65 citations , April 2020 in “International Journal of Molecular Sciences”

This review indicates that most studies reported positive effects of platelet-rich plasma injections for treating androgenic alopecia, with no major side effects, suggesting it may be a safe alternative to Minoxidil and Finasteride.

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87 citations , March 2020 in “Australian Dental Journal”

This review discusses different preparation and application methods of platelet-rich plasma in dental regenerative medicine and reports no new results, highlighting its potential and associated controversies.

research Platelet-Rich Plasma: The Journey So Far

18 citations , January 2020 in “Indian Dermatology Online Journal”

This review summarizes available evidence on the dermatological use of platelet-rich plasma, particularly noting its efficacy for androgenetic alopecia and skin rejuvenation, but highlights significant gaps due to limited high-quality studies.

research Platelet-Rich Plasma and Its Utilities in Alopecia: A Systematic Review

21 citations , June 2019 in “Dermatologic Surgery”

This research review found that platelet-rich plasma treatment generally produced successful hair regrowth in both androgenetic alopecia and alopecia areata, despite study differences that limited direct statistical comparison.

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12 citations , June 2019 in “Clinics in dermatology”

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42 citations , February 2018 in “International Journal of Molecular Sciences”

This study suggests that minoxidil may enhance hair growth by stimulating adipose-derived stem cell motility and growth factor secretion, promoting dermal papilla cell proliferation and accelerating anagen induction.

Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

research Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

136 citations , February 2017 in “International Journal of Molecular Sciences”

This study observed that autologous platelet-rich plasma treatment improved hair count and density in areas with androgenetic alopecia compared to placebo, with differing outcomes based on the PRP collection device used.

research Systematic Review of the Use of Platelet-Rich Plasma in Aesthetic Dermatology

113 citations , July 2015 in “Journal of Cosmetic Dermatology”

This review discusses the cosmetic applications of platelet-rich plasma in dermatology, highlighting its potential benefits and the need for more controlled studies.

research Fibroblast Growth Factors Stimulate Hair Growth Through Beta-Catenin and Shh Expression in C57BL/6 Mice

64 citations , January 2015 in “BioMed Research International”

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research Platelet-Rich Plasma as a Potential Treatment for Noncicatricial Alopecias

58 citations , January 2015 in “International Journal of Trichology”

This review evaluates the therapeutic potential of platelet-rich plasma for treating non-cicatricial alopecias and suggests it may be effective, though further research is needed to confirm its efficacy.

research Study of Platelet-Rich Plasma Injections in the Treatment of Androgenetic Alopecia Through a One-Year Period

164 citations , January 2014 in “Journal of Cutaneous and Aesthetic Surgery”

This study found that PRP injections may improve hair density and reduce hair loss in patients with androgenetic alopecia without significant side effects, but further research is needed to confirm efficacy.

research Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

270 citations , March 2012 in “Dermatologic Surgery”

This study found that autologous platelet-rich plasma increased hair growth potential by enhancing dermal papilla cell proliferation and stimulating key signaling pathways in both cell cultures and mice models.

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94 citations , February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study concluded that epidermal growth factor may induce a 'catagen-like' phase in human hair follicles by disrupting normal cellular proliferation and migration patterns.