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research ILK modulates epithelial polarity and matrix formation in hair follicles

22 citations , December 2013 in “Molecular biology of the cell”

This study found that ILK deficiency disrupts hair follicle development by impairing cell polarity and laminin-511 assembly, but these defects can be partially reversed with exogenous laminin-511.

research Matrix Metalloproteinase-9 Is Involved in the Regulation of Hair Canal Formation

20 citations , September 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that MMP-9 plays a significant role in extracellular matrix remodeling during hair canal formation in mice, as indicated by delayed hair shaft emergence and hair canal development in MMP-9 knockout mice.

research Effects of porcine acellular dermal matrix treatment on wound healing and scar formation: Role of Jag1 expression in epidermal stem cells

10 citations , January 2018 in “Organogenesis”

This study found that epidermal stem cell-specific Jag1 expression levels are crucial for effective wound healing and scar reduction, and porcine acellular dermal matrix treatment enhances this process in mice by boosting Notch/Jagged1 signaling.

research Intraoperative Bioprinting of Human Adipose-derived Stem cells and Extra-cellular Matrix Induces Hair Follicle-Like Downgrowths and Adipose Tissue Formation during Full-thickness Craniomaxillofacial Skin Reconstruction

1 citations , October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study demonstrated that intraoperative bioprinting using a bioink with human adipose-derived extracellular matrix and stem cells achieved successful reconstruction of full-thickness craniomaxillofacial skin defects in rats, promoting wound closure, adipogenesis, and hair follicle-like structure formation within two weeks.

research Epithelial loss of mitochondrial oxidative phosphorylation leads to disturbed enamel and impaired dentin matrix formation in postnatal developed mouse incisor

3 citations , December 2020 in “Scientific reports”

This study found that mitochondrial oxidative phosphorylation in epithelial cells is necessary for proper enamel formation and odontoblast differentiation in developing incisor teeth in K320E-Twinkle Epi mice.

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Community Join

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community Why you can still look forward to PP405 and JXL-069

22 upvotes 2 months ago

PP405 and JXL-069 are the same compound, but users experienced no results due to flawed application methods. The topical gel formulation of PP405 is designed to target hair follicle stem cells effectively, unlike liquid solutions that fail to penetrate deeply.

community Turkey is constantly pouring money into fear mongering around finasteride in order to protect its hair transplant economy

119 upvotes 6 months ago

Finasteride and minoxidil are commonly recommended by hair transplant clinics, including those in Turkey, despite some negative perceptions and concerns about side effects. The conversation highlights differing opinions on the effectiveness and safety of these treatments, with some users expressing skepticism about side effects and others emphasizing the importance of these medications for successful hair transplants.

community Anyone tried Anagen “Smooth Release” oral minoxidil?

9 upvotes 1 week ago

People are discussing Anagen's "Smooth Release" oral minoxidil, with some users reporting no side effects or hair growth yet. There are concerns about a potential lawsuit with Veradermics over intellectual property, but no confirmed legal action has been found.

community DIY NutraKos-style 6–amino-acid mix (recipe + references)

1 upvotes 7 months ago

A user shared a DIY recipe for a NutraKos-style amino acid mix as a cost-effective alternative to the expensive product, suggesting it as a complementary supplement for hair loss. Another user argued that proven treatments like finasteride and minoxidil are more reliable, questioning the efficacy of the amino acid mix.

community 21m, 2.5 months on 1mg dut & 2.5mg min

in Progress Pictures 10 upvotes 1 year ago

A 21-year-old male has been using dutasteride, minoxidil, ketoconazole shampoo, and microneedling for hair loss, with plans to increase minoxidil dosage. He is experiencing no side effects and is planning a trichoscopy to assess hair regrowth.

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